CYP1A1 and AKR7A3

		CYP1A1	AKR7A3
Description		cytochrome P450 family 1 subfamily A member 1	aldo-keto reductase family 7 member A3
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GO Annotations	Cellular Component	Mitochondrial Inner Membrane Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonic Acid Monooxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors Flavonoid 3'-monooxygenase Activity Oxygen Binding Enzyme Binding Heme Binding Hsp70 Protein Binding Demethylase Activity Hsp90 Protein Binding Aromatase Activity Vitamin D 24-hydroxylase Activity Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity	Aldo-keto Reductase (NADP) Activity Protein Binding Electron Transfer Activity Identical Protein Binding D-threo-aldose 1-dehydrogenase Activity
	Biological Process	Response To Hypoxia Lipid Hydroxylation DNA Methylation Fatty Acid Metabolic Process Steroid Biosynthetic Process Porphyrin-containing Compound Metabolic Process Xenobiotic Metabolic Process Aging Steroid Metabolic Process Estrogen Metabolic Process Cell Population Proliferation Amine Metabolic Process Response To Xenobiotic Stimulus Response To Wounding Response To Virus Response To Nematode Response To Herbicide Ethylene Metabolic Process Coumarin Metabolic Process Flavonoid Metabolic Process Response To Iron(III) Ion Insecticide Metabolic Process Dibenzo-p-dioxin Catabolic Process Epoxygenase P450 Pathway Response To Food Response To Lipopolysaccharide Response To Vitamin A Response To Immobilization Stress Vitamin D Metabolic Process Retinol Metabolic Process Long-chain Fatty Acid Biosynthetic Process 9-cis-retinoic Acid Biosynthetic Process Camera-type Eye Development Response To Antibiotic Response To Arsenic-containing Substance Digestive Tract Development Hydrogen Peroxide Biosynthetic Process Response To Hyperoxia Maternal Process Involved In Parturition Hepatocyte Differentiation Demethylation Cellular Response To Copper Ion Cellular Response To Organic Cyclic Compound Omega-hydroxylase P450 Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Cellular Aldehyde Metabolic Process Electron Transport Chain Aflatoxin Catabolic Process
Pathways		PPARA activates gene expression Xenobiotics Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of protectins	Aflatoxin activation and detoxification
Drugs		2-Methoxyestradiol Indirubin Nabiximols
Diseases
GWAS		Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Caffeine consumption ( 21490707) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Clozapine concentration in schizophrenia ( 32555152) Coffee consumption ( 21876539 21357676 31046077 25288136) Coffee consumption (cups per day) ( 31837886 25288136) Diastolic blood pressure ( 26390057 19430483 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Estimated glomerular filtration rate ( 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Microalbuminuria ( 31511532) Plasma clozapine levels in treatment-resistant schizophrenia ( 30922102) Platelet distribution width ( 27863252) Relative carbohydrate intake ( 32393786) Sweet beverage consumption ( 31046077) Systolic blood pressure ( 21909115 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Tea consumption ( 31046077) Urate levels ( 31578528) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 30910378 31511532) Urinary potassium excretion ( 31409800) Urinary sodium excretion ( 31409800)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Late-onset Alzheimer's disease ( 27770636)
Interacting Genes		10 interacting genes: AKR7A3 CELF6 CEMIP CMTM5 COX5A CYB5A CYP1A2 FBXW5 VAMP4 ZNF189	5 interacting genes: AKR7A2 CYP1A1 KRT31 KRTAP1-1 TERF2IP
Entrez ID		1543	22977
HPRD ID		00148	07089
Ensembl ID		ENSG00000140465	ENSG00000162482
Uniprot IDs		A0N0X8 E7EMT5 P04798	A0A384MDN8 O95154
PDB IDs		4I8V 6DWM 6DWN 6O5Y 6UDL 6UDM	2CLP
Enriched GO Terms of Interacting Partners?
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