CYBB and NCF2

Number of citations of the paper that reports this interaction (PubMedID 11893732)
98

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		CYBB	NCF2
Description		cytochrome b-245 beta chain	neutrophil cytosolic factor 2
Image
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Dendrite Phagocytic Vesicle Membrane Specific Granule Membrane NADPH Oxidase Complex Neuronal Cell Body Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum	Acrosomal Vesicle Cytosol Membrane Phagolysosome NADPH Oxidase Complex
	Molecular Function	Voltage-gated Ion Channel Activity Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Heme Binding Metal Ion Binding Protein Heterodimerization Activity Flavin Adenine Dinucleotide Binding	Protein Binding Protein C-terminus Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity Small GTPase Binding
	Biological Process	Superoxide Metabolic Process Defense Response Inflammatory Response Response To Nutrient Response To Xenobiotic Stimulus Electron Transport Chain Positive Regulation Of Tumor Necrosis Factor Production Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Superoxide Anion Generation Innate Immune Response Respiratory Burst Positive Regulation Of Angiogenesis Cellular Response To Cadmium Ion Cellular Response To Ethanol Hypoxia-inducible Factor-1alpha Signaling Pathway Response To Aldosterone Cellular Response To L-glutamine Response To Angiotensin	Superoxide Metabolic Process Phagocytosis Cellular Defense Response Electron Transport Chain Superoxide Anion Generation Innate Immune Response Respiratory Burst Regulation Of Catalytic Activity
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs		Dextromethorphan	Dextromethorphan
Diseases
GWAS			Celiac disease ( 31591516) Celiac disease and Rheumatoid arthritis ( 26546613) Systemic lupus erythematosus ( 27399966 26606652 33272962 26502338 28714469 19838195) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Interacting Genes		8 interacting genes: ACTG1 CYBA CYBC1 DYNLT3 IQGAP1 NCF2 NCF4 RAC1	15 interacting genes: AKT1 CDC42 CYBA CYBB GOLGA2 KIFAP3 NCF1 NCF4 PRDX6 PRKDC RAC1 RAC2 S100A8 S100A9 SYTL1
Entrez ID		1536	4688
HPRD ID		02382	01991
Ensembl ID		ENSG00000165168	ENSG00000116701
Uniprot IDs		A0A0S2Z3S6 P04839	A0A0S2Z457 P19878
PDB IDs		3A1F	1E96 1HH8 1K4U 1OEY 1WM5 2DMO
Enriched GO Terms of Interacting Partners?
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