ADRA2C and CCDC24

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ADRA2C	CCDC24
Description		adrenoceptor alpha 2C	coiled-coil domain containing 24
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane Neuronal Cell Body Axon Terminus Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	G Protein-coupled Receptor Activity Alpha2-adrenergic Receptor Activity Protein Binding Alpha-2A Adrenergic Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding	Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Negative Regulation Of Norepinephrine Secretion Platelet Activation Activation Of Protein Kinase B Activity Negative Regulation Of Epinephrine Secretion Receptor Transactivation Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Vasoconstriction Regulation Of Sensory Perception Of Pain Negative Regulation Of Uterine Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway	Blastocyst Hatching
Pathways		Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor Adrenaline,noradrenaline inhibits insulin secretion G alpha (i) signalling events G alpha (z) signalling events Surfactant metabolism
Drugs		Amphetamine Tramadol Bethanidine Ziprasidone Cabergoline Ropinirole Clozapine Norepinephrine Phenylpropanolamine Loxapine Prochlorperazine Chlorpromazine Brimonidine Haloperidol Nortriptyline Amoxapine Clonidine Lisuride Ergotamine Tizanidine Apomorphine Paroxetine Risperidone Tolazoline Fenoldopam Phenoxybenzamine Maprotiline Oxymetazoline Ergoloid mesylate Promethazine Carvedilol Desipramine Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra sinica root Mephentermine Yohimbine Methotrimeprazine Dextroamphetamine Metamfetamine Celiprolol Dronedarone Iloperidone OPC-28326 Epicept NP-1 Mianserin Pizotifen Asenapine Ocaperidone Droxidopa Esmirtazapine Xylometazoline Levonordefrin Lurasidone Agmatine Brexpiprazole Dosulepin Etoperidone Lorpiprazole Cirazoline Moxisylyte Aranidipine Setiptiline Racepinephrine Dihydroergocornine DL-Methylephedrine Xylazine Indigotindisulfonic acid Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Lung cancer in ever smokers ( 28604730) Nickel levels ( 26025379) Urinary potassium excretion ( 31409800)	Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		18 interacting genes: CCDC24 CHCHD2 CNPY2 EIF2B1 GNAO1 HGS KLHL38 KRT34 MDFI MEIS2 MGAT5B MKRN3 P4HA3 PPP1R9B UCHL1 WFS1 WWOX YWHAZ	39 interacting genes: ADRA2C AKAP8L ANTKMT ARMH1 CDC23 DISC1 DYNLT4 FAM166B FNTB GATA1 HPDL HYI IKZF3 KLF17 KRT33B KRT34 KRTAP13-2 KRTAP15-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP6-1 KRTAP6-3 LRP2BP MAGEA6 NDUFAB1 NDUFB7 OIP5 REN RNF31 TCEAL8 TRIM42 TRIP6 TTC23 TTC23L USHBP1 USP54 WWOX ZMYND12
Entrez ID		152	149473
HPRD ID		00085	14636
Ensembl ID		ENSG00000184160	ENSG00000159214
Uniprot IDs		P18825 Q4W594	Q8N4L8
PDB IDs		6KUW
Enriched GO Terms of Interacting Partners?
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