LRATD1 and ARHGEF5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LRATD1	ARHGEF5
Description		LRAT domain containing 1	Rho guanine nucleotide exchange factor 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Junction Cell Projection Cell Periphery
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Lipid Binding
	Biological Process	Cell Morphogenesis Cell Motility	Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Regulation Of ERK1 And ERK2 Cascade Activation Of GTPase Activity Positive Regulation Of Protein Import
Pathways			NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS			Breast cancer ( 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Gut microbiota relative abundance (Parabacteroides) ( 33208821) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		2 interacting genes: ARHGEF5 CYGB	29 interacting genes: APP ATP13A1 CALCOCO2 CCNE1 CHPF COG6 EFHC2 EPM2AIP1 FKBP8 HSF2BP HSPBAP1 LMO2 LRATD1 MB21D2 MID2 NR4A1 PICK1 PLCG1 PLEKHG4 POLR1C RHOA SEPHS2 SLAIN1 SLU7 TBC1D13 TCF4 TRIM27 TRIM54 ZRANB1
Entrez ID		151354	7984
HPRD ID		17647	02932
Ensembl ID		ENSG00000162981	ENSG00000050327
Uniprot IDs		Q96KN4	Q12774
PDB IDs
Enriched GO Terms of Interacting Partners?
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