NFAM1 and BCL11A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NFAM1	BCL11A
Description		NFAT activating protein with ITAM motif 1	BAF chromatin remodeling complex subunit BCL11A
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Azurophil Granule Membrane Membrane Raft	Nucleus Nucleoplasm Chromosome Cytoplasm Postsynaptic Density Nuclear Matrix
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Kinase Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Cytokine Production Inflammatory Response Signal Transduction B Cell Differentiation Intracellular Signal Transduction Regulation Of B Cell Differentiation B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Protein Sumoylation Negative Regulation Of Dendrite Extension Negative Regulation Of Neuron Remodeling Cellular Response To L-glutamate Negative Regulation Of Dendrite Development Negative Regulation Of Branching Morphogenesis Of A Nerve
Pathways		Neutrophil degranulation	ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Chronotype ( 30696823) Machado-Joseph disease (age at onset) ( 32205469) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258)	Acne (severe) ( 24927181 30542056) Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Attention deficit hyperactivity disorder ( 22012869) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Beta thalassemia/hemoglobin E disease ( 20183929) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Childhood absence epilepsy ( 30531953) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Epilepsy ( 30531953) F-cell distribution ( 17767159) F-cell distribution in sickle cell anaemia ( 21326311) Face memory ( 31596458) Falling risk ( 32999390) Fetal hemoglobin levels ( 18245381 20018918) Fetal hemoglobin levels in sickle cell anemia ( 25372704) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Generalized epilepsy ( 30531953) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heel bone mineral density ( 30598549) Hemoglobin A2 levels in sickle cell anemia ( 25042611) Hemoglobin levels ( 26366553) High fetal hemoglobin in sickle cell disease ( 27022141) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285) Immature fraction of reticulocytes ( 32888494 27863252) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252 28017375 19862010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Methadone dose in opioid dependence ( 28115739) Monocyte early outgrowth colony forming units ( 21493818) Morning person ( 30696823) Number of sexual partners ( 30643258) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Prostate-specific antigen levels ( 30410027 28139693) Red blood cell count ( 32888494 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Refractive error ( 32231278) Resting heart rate ( 27798624) Risk-taking tendency (4-domain principal component model) ( 30643258) Sickle cell anemia (haemolysis) ( 23406172) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 1 diabetes ( 34012112) Type 2 diabetes ( 22885922 24509480 29358691 30297969 32499647 20581827 30718926 28869590) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Walking pace ( 33128006)
Interacting Genes		6 interacting genes: BCL11A CHADL MAL2 SYK TCF4 ZAP70	30 interacting genes: ACTC1 APP BCL6 CDCA3 CDK4 CDK6 EZH2 FXR2 GMCL2 HDAC1 HDAC2 LMO1 MORF4L2 MTA1 NCK2 NFAM1 NR2E3 NR2F1 NR2F2 NR2F6 PIN1 RBBP4 RBBP7 SIN3A SIRT1 SUZ12 TSC1 UBE2I YME1L1 ZBTB24
Entrez ID		150372	53335
HPRD ID		16380	05949
Ensembl ID		ENSG00000235568	ENSG00000119866
Uniprot IDs		Q8NET5	D9YZV9 D9YZW0 Q9H165
PDB IDs			5VTB 6KI6 6U9Q
Enriched GO Terms of Interacting Partners?
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