CTNND1 and CDH5

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		CTNND1	CDH5
Description		catenin delta 1	cadherin 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Catenin Complex Lamellipodium Growth Cone Midbody Dendritic Spine Extracellular Exosome Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Nucleoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Catenin Complex Cell Junction Nuclear Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Protein Kinase Binding Cadherin Binding	Signaling Receptor Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Vascular Endothelial Growth Factor Receptor 2 Binding Transmembrane Transporter Binding Cadherin Binding Fibrinogen Binding BMP Receptor Binding Protein Tyrosine Kinase Binding
	Biological Process	Cell-cell Junction Assembly Brain Development Wnt Signaling Pathway Cell-cell Adhesion Mediated By Cadherin Protein Stabilization Negative Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Cell Morphogenesis Regulation Of Protein Phosphorylation Vasculature Development Blood Vessel Maturation Cellular Calcium Ion Homeostasis Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Transforming Growth Factor Beta Receptor Signaling Pathway Multicellular Organism Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Microtubule Polymerization Positive Regulation Of Protein-containing Complex Assembly Adherens Junction Organization Positive Regulation Of Protein Dephosphorylation Maintenance Of Blood-brain Barrier Regulation Of Vascular Permeability Blood Vessel Endothelial Cell Migration Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Bicellular Tight Junction Assembly Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Protein Localization To Bicellular Tight Junction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability InlA-mediated entry of Listeria monocytogenes into host cells	Adherens junctions interactions VEGFR2 mediated vascular permeability
Drugs			Lenalidomide FX06
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) High light scatter reticulocyte percentage of red cells ( 32888494) Household income (MTAG) ( 31844048) Neuroticism ( 29255261) Parkinson's disease ( 27182965) Pulse pressure ( 27841878 30578418) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 25056061 29483656) Systolic blood pressure ( 27841878)	Body size at age 10 ( 32376654) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High light scatter reticulocyte count ( 32888494) Iron status biomarkers (ferritin levels) ( 28334935) Lung function (FEV1/FVC) ( 30061609) Molar-incisor hypomineralization ( 23918034) Reticulocyte count ( 32888494)
Interacting Genes		32 interacting genes: ACTA1 APP CDH1 CDH24 CDH3 CDH5 COL17A1 CTTN EGFR ERBIN FER GRIK2 GSK3B JUP KCTD6 MAPK1 MAPK3 MTNR1B MUC1 OGT PLPP3 PSEN1 PTPN6 PTPRJ PTPRM RPS6KA3 SMURF1 SNCA SRC SUMO2 YWHAG ZBTB33	28 interacting genes: CA7 CDH1 CDH16 CDH3 CSK CTNNA1 CTNNB1 CTNND1 DSP EGFR EPHA2 F2RL2 FGA JUP KDR NQO1 P2RX4 P2RX6 PARD6A PKP4 PTPN11 PTPRB PYGB RND3 SHC1 SMG1 SRC VIM
Entrez ID		1500	1003
HPRD ID		03026	03075
Ensembl ID		ENSG00000198561	ENSG00000179776
Uniprot IDs		O60716	P33151 Q59EA3
PDB IDs		3L6X 3L6Y
Enriched GO Terms of Interacting Partners?
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