CNIH3 and KCNN4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CNIH3	KCNN4
Description		cornichon family AMPA receptor auxiliary protein 3	potassium calcium-activated channel subfamily N member 4
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane ER To Golgi Transport Vesicle Membrane Dendrite AMPA Glutamate Receptor Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Dendritic Shaft Synapse Postsynaptic Membrane	Plasma Membrane Voltage-gated Potassium Channel Complex Vesicle Neuron Projection Neuronal Cell Body
	Molecular Function	Protein Binding Channel Regulator Activity	Potassium Channel Activity Protein Binding Calmodulin Binding Calcium-activated Potassium Channel Activity Small Conductance Calcium-activated Potassium Channel Activity Protein Phosphatase Binding Intermediate Conductance Calcium-activated Potassium Channel Activity
	Biological Process	Vesicle-mediated Transport Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Regulation Of AMPA Receptor Activity	Immune System Process Ion Transport Potassium Ion Transport Calcium Ion Transport Cell Volume Homeostasis Defense Response Stabilization Of Membrane Potential Phospholipid Translocation Saliva Secretion Positive Regulation Of Protein Secretion Positive Regulation Of T Cell Receptor Signaling Pathway Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER	Ca2+ activated K+ channels
Drugs			Clotrimazole Quinine Procaine Miconazole Halothane Trimebutine
Diseases
GWAS		Cancer ( 29299148) Gut microbiota relative abundance (Streptococcus) ( 33208821) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 32888494) Neonatal white matter microstructure ( 33009551) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Opioid dependence ( 26239289) White blood cell count ( 32888494)	Breast cancer ( 23535729) Granulocyte percentage of myeloid white cells ( 27863252) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean platelet volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		29 interacting genes: AQP6 BIK CD79A CEACAM3 CLDN20 DNAH14 ERGIC3 FAM210B FNDC9 GPX8 KCNN4 LEUTX LMNA LRRC25 NEMP1 ODF4 PLD3 SLC16A2 SMIM3 SORT1 STOM SUSD3 TMEM14B TMEM237 TMEM31 TMEM52B TMEM80 TMPRSS2 VSIR	9 interacting genes: BIK CALM1 CNIH3 FXYD3 GPR152 PMP22 PRKAG1 SLC30A2 STX1B
Entrez ID		149111	3783
HPRD ID		08799	04130
Ensembl ID		ENSG00000143786	ENSG00000104783
Uniprot IDs		Q8TBE1	O15554
PDB IDs			6CNM 6CNN 6CNO 6D42
Enriched GO Terms of Interacting Partners?
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