CTBP2 and LCORL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		CTBP2	LCORL
Description		C-terminal binding protein 2	ligand dependent nuclear receptor corepressor like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Repressor Complex Photoreceptor Ribbon Synapse Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse Presynaptic Cytosol	Nucleus
	Molecular Function	Transcription Corepressor Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Kinase Binding Retinoic Acid Receptor Binding Protein-containing Complex Binding NAD Binding Structural Constituent Of Presynaptic Active Zone	DNA Binding Protein Binding Histone Methyltransferase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Synaptic Vesicle Docking Viral Genome Replication Positive Regulation Of Chromatin Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Maintenance Of Presynaptic Active Zone Structure White Fat Cell Differentiation Cellular Response To Leukemia Inhibitory Factor	Regulation Of Transcription By RNA Polymerase II
Pathways		Repression of WNT target genes Signaling by TCF7L2 mutants
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age-related cognitive decline (visuospatial skill) (slope of z-scores) ( 30954325) Apolipoprotein A1 levels ( 32203549) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Haemorrhoidal disease ( 33888516) HDL cholesterol levels ( 32203549) Height ( 25429064) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Infant, child and juvenile death in continuous marriage (proportion of children died <15 years) ( 30188897) Menarche (age at onset) ( 25231870) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 18264096) Red blood cell count ( 32888494) Refractive error ( 32231278) Vigorous physical activity ( 29899525) Walking pace ( 33128006)	Adult body size ( 32376654) Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Alanine aminotransferase levels ( 33547301) Alzheimer's disease progression score ( 29860282) Birth length ( 25281659) Birth weight ( 23202124 31043758 27680694) BMI at 1 year old ( 31575865) BMI at 1.5 years old ( 31575865) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronotype ( 30696823) Colorectal cancer (diet interaction) ( 24743840) Diverticular disease ( 30177863) Familial squamous cell lung carcinoma ( 29924316) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549) Height ( 21998595 28552196 20881960 22021425 25282103 25429064 19343178 23563607 31562340 28270201 18391951 18391952 33713608 20189936) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172 25673412) Infant length ( 25281659) Offspring birth weight ( 31043758) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 30224653 30578418) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 34021172 25673412) Weight ( 28552196) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		99 interacting genes: ACTG1 AKTIP APP ATE1 BAZ2B BCAS3 BCL3 C15orf39 CACNB1 CACNB2 CACNB3 CACNB4 CAPN7 CASP8AP2 CATSPER1 CBX4 CCDC120 CCNH CCR5 CDKN2A CEP68 CSTF2 CTBP1 CTPS2 DMRTB1 DTNB DUSP21 DVL2 EEF1D EGLN3 EIF4G1 ELAC2 ENKD1 EP300 FHL3 FLI1 FOXP2 FUNDC1 GLIS2 H3-4 HEMGN HIC1 HOXA5 HOXB5 HOXC5 IKZF1 IKZF2 KCNIP3 KLF3 KLF8 KYNU LCORL LMO4 MDM2 MECOM MSRB3 NEK6 NOL4 NOL4L NRIP1 PLCB1 PNN PPP1R15A PROX1 PSMF1 QARS1 RAI2 RBBP8NL RIMBP3 RNF135 RPL17 RPL7A RPS28 RPS29 RPS4X SDCBP SHISA6 SOX13 SOX6 STUB1 STX11 TEAD3 TGIF1 TLE5 TRIML2 TSHZ3 UBC UBE2I VRTN XRCC6 ZBP1 ZBTB42 ZEB1 ZEB2 ZFPM1 ZFPM2 ZNF512B ZNF750 ZSCAN4	3 interacting genes: CTBP2 MAGEA6 MIR206
Entrez ID		1488	254251
HPRD ID		04016	10088
Ensembl ID		ENSG00000175029	ENSG00000178177
Uniprot IDs		P56545	A0A1B0GVP4 B4DSW0 Q8N3X6
PDB IDs		2OME 4LCJ 6WKW
Enriched GO Terms of Interacting Partners?
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