CTBP1 and TCF4

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid, two hybrid)

		CTBP1	TCF4
Description		C-terminal binding protein 1	transcription factor 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Repressor Complex Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse	Chromatin Nucleus Transcription Regulator Complex Beta-catenin-TCF7L2 Complex Beta-catenin-TCF Complex
	Molecular Function	Transcription Corepressor Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Domain Specific Binding Identical Protein Binding NAD Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific TFIIB-class Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Identical Protein Binding Protein Heterodimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Viral Genome Replication Positive Regulation Of Histone Deacetylation Negative Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated White Fat Cell Differentiation Regulation Of Cell Cycle Negative Regulation Of Histone H4 Acetylation	Regulation Of Transcription By RNA Polymerase II Nervous System Development Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein-DNA Complex Assembly
Pathways		Deactivation of the beta-catenin transactivating complex SUMOylation of transcription cofactors Repression of WNT target genes Signaling by TCF7L2 mutants	Myogenesis Myogenesis
Drugs		Formic acid
Diseases
GWAS		Type 2 diabetes ( 31118516 32499647)	Ability to confide in someone ( 29970889) Adult body size ( 32376654) Adventurousness ( 30643258) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Automobile speeding propensity ( 30643258) Bitter alcoholic beverage consumption ( 31046077) Brain morphology (MOSTest) ( 32665545) Broad depression or schizophrenia ( 30626913) Chin dimples ( 27182965) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Corneal endothelial cell density ( 30894546) Corneal endothelial cell shape (percentage of hexagonally shaped cells) ( 30894546) Corneal hysteresis ( 32716492 30894546) Corneal resistance factor ( 31246245 32716492 30894546) Cutaneous leishmaniasis ( 32830257) Depression ( 33859377 29700475) Diabetic retinopathy ( 21441570) Diastolic blood pressure ( 30224653) Experiencing mood swings ( 29500382) Feeling fed-up ( 29500382) Feeling lonely ( 29500382) Feeling worry ( 29500382) Fuchs's corneal dystrophy ( 28358029 20825314) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431 29313844) Heart rate response to exercise ( 29769521) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Intraocular pressure ( 29617998 31798171 29235454) Irritable mood ( 29500382) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Male-pattern baldness ( 28196072) Mental health study participation (completed survey) ( 31263887) Mood instability ( 31168069) Morning person ( 30696823) Neurociticism ( 29500382) Number of sexual partners ( 30643258) Obesity (early onset extreme) ( 23563609) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Pulse pressure ( 30578418) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 28991256 25056061 21926974 19571808 19571811 29483656 22688191 30285260 23974872 23894747) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Self-rated health ( 27864402) Self-reported risk-taking behaviour ( 30271922) Sleep duration (short sleep) ( 30846698) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Surgical recurrence in Crohn's disease ( 33724339) Systolic blood pressure ( 30578418) Tea consumption ( 31046077) Type 2 diabetes ( 30297969) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Walking pace ( 33128006)
Interacting Genes		91 interacting genes: ACTL6B AKAP9 APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CDC23 CDKN2D CEP68 CHD3 CREBBP CRY2 CTBP2 CTNNA1 DGCR6 DMRTB1 EEF1D ELAC2 ELK3 EP300 FANCC FANCF FANCG FANCL FOXP1 FOXP2 FUNDC1 GTF2B H3-4 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HEMGN HIC1 HOXB5 HTT IKZF1 IKZF2 KAT2B KDM1A KLF12 KLF3 LNX1 MAML2 MAPK9 MARCHF10 MECOM NME2 NOL4 NOL4L NOS1 NRIP1 NTAQ1 ORC4 PIAS2 PLCB1 PNN PRKAA1 PRKCI RAI2 RB1 RBBP5 RBBP8 RBM14 RCOR1 RNF111 SIN3A SNRPN SOBP SPEN TBP TCF4 TEAD4 TERF2 TERF2IP TGIF1 THAP11 TSHZ3 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM2 ZNF219	235 interacting genes: ALKBH4 AQP1 AR ARHGEF1 ARHGEF5 ARL16 ARMC7 ASAP3 ASCL1 ASCL3 ASCL4 ASPSCR1 ATG9A ATOH7 ATP11B ATP6V1B2 BACH1 BANF2 BCAS2 BCL2L15 BCL2L2 C1orf109 C1orf50 C1orf56 CABP5 CALM1 CALM2 CALM3 CASR CBFA2T2 CCNH CDC37 CDC73 CDKN1A CDKN2C CFAP77 CHAF1A CHCHD2 CHIC2 CKS1B CLCNKA COA5 CPNE2 CTBP1 CTIF CTNNB1 DAXX DDX6 DEF6 DENND2B DGCR6 DMRT3 DNTT DUSP23 DUSP29 EFHC1 EIF4E2 EIF4EBP1 EP300 EPB41L3 EPHB6 EXOC8 EXOSC1 FAH FAM110A FAM124B FAM74A4 FERD3L FIGLA FLAD1 FLNA FRS3 GEM GLRX3 GNG10 GOLGA8EP GOLGA8F GORASP2 GTF3C5 GUCD1 HAND2 HAT1 HBP1 HSPB7 ID1 ID2 ID3 ID4 INS JUN JUP KCTD14 KLC3 KLHL32 KLHL38 LASP1 LENG1 LGALS14 LHX4 LIPG LMO1 LMO4 LNPEP LYL1 MAD2L2 MAGOHB MAPKBP1 MARF1 MATN3 MEMO1 MLLT6 MORN4 MRFAP1L1 MRPL10 MSC MSGN1 MSRB3 MVP MYO15B MYO5B MYOD1 NCK2 NDOR1 NECTIN2 NEK6 NEK8 NEU4 NEUROD1 NEUROD4 NEUROG1 NEUROG3 NFAM1 NFKBID NHLH2 NME7 NMUR2 NOL9 NOXA1 NR2C2AP NR4A1 NUDT10 NUDT22 NXPE2 NXT2 OLFM3 ORC4 OSGIN1 OTUD4 PARP1 PATE1 PBLD PIAS2 PIN1 PLEKHN1 POLR1A POLR1C PPIA PPIL1 PPP1R18 PRKAA2 PRKAB2 PRKACA PRKN PSMA1 PSMG2 PTF1A PTGER3 RAB41 RABIF RAD51D RECK RELA REXO1L6P RNF6 RPL18A RSPH14 RUNX1T1 SCOC SCX SDCBP SEC14L4 SETBP1 SGF29 SHFL SIGLEC6 SLC39A13 SLC4A1AP SMAD2 SMCP SMG9 SMOC1 SPATC1L SPG21 SPO11 SRSF2 STAMBPL1 STK16 STX11 SZT2 TAL1 TAL2 TAPBPL TCEA2 TCF23 TCF24 TCF3 TCL1A TLE1 TLE5 TMEM213 TP53 TRAPPC2L TRIM68 TRIML2 TSPOAP1 TSSC4 TSSK3 TSTD2 TTF2 TWIST1 TWIST2 TXNL4B UBASH3B UBE2I UTP23 VPS28 XRCC5 XRCC6 ZDHHC24 ZMYND10 ZNF124 ZNF205-AS1 ZNF417 ZNF587 ZNF688
Entrez ID		1487	6925
HPRD ID		04015	03780
Ensembl ID		ENSG00000159692	ENSG00000196628
Uniprot IDs		Q13363 X5D8Y5	A0A024R2C0 A0A1B0GW91 A0A1B0GWD5 B3KVA4 E9PH57 H3BPJ7 H3BTP3 P15884
PDB IDs		1MX3 4LCE 4U6Q 4U6S 6CDF 6CDR 6V89 6V8A 7KWM	2KWF 6OD3 6OD4 6OD5
Enriched GO Terms of Interacting Partners?
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