ADRA1B and PPP1R9B

Number of citations of the paper that reports this interaction (PubMedID 17464283)
25

Data Source:
HPRD (in vitro)

		ADRA1B	PPP1R9B
Description		adrenoceptor alpha 1B	protein phosphatase 1 regulatory subunit 9B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Caveola Nuclear Membrane	Protein Phosphatase Type 1 Complex Nucleoplasm Cytoplasm Plasma Membrane Adherens Junction Postsynaptic Density Actin Cytoskeleton Lamellipodium Filopodium Dendrite Growth Cone Cortical Actin Cytoskeleton Ruffle Membrane Neuronal Cell Body Dendritic Spine Neck Dendritic Spine Head Cytoplasmic Side Of Dendritic Spine Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Activity Alpha1-adrenergic Receptor Activity Protein Binding Protein Heterodimerization Activity	Protein Kinase Activity Protein Phosphatase Inhibitor Activity Protein Binding Protein C-terminus Binding Protein Phosphatase 1 Binding Kinase Binding D2 Dopamine Receptor Binding Transmembrane Transporter Binding Actin Filament Binding
	Biological Process	Positive Regulation Of Heart Rate By Epinephrine-norepinephrine G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Vasoconstriction Regulation Of Cardiac Muscle Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Neuron-glial Cell Signaling	Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Protein Phosphorylation Response To Amphetamine Developmental Process Involved In Reproduction Protein Phosphorylation Actin Filament Organization Regulation Of Exit From Mitosis Aging Learning RNA Splicing Dendrite Development Cell Migration Calcium-mediated Signaling Hippocampus Development Cerebral Cortex Development Actin Filament Depolymerization Negative Regulation Of Cell Growth Neuron Projection Development Negative Regulation Of Phosphoprotein Phosphatase Activity Response To Prostaglandin E Response To Nicotine Response To Immobilization Stress Regulation Of Cell Population Proliferation Filopodium Assembly Response To Steroid Hormone Modulation Of Chemical Synaptic Transmission Regulation Of Cell Cycle Male Mating Behavior Reproductive System Development Cellular Response To Morphine Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Xenobiotic Stimulus Response To Clozapine Cellular Response To Peptide Positive Regulation Of Protein Localization To Plasma Membrane Protein Localization To Actin Cytoskeleton Positive Regulation Of Protein Localization To Actin Cortical Patch Response To Kainic Acid Response To L-phenylalanine Derivative Protein Localization To Cell Periphery Regulation Of Opioid Receptor Signaling Pathway
Pathways		Adrenoceptors G alpha (q) signalling events G alpha (12/13) signalling events
Drugs		Amphetamine Midodrine Ranolazine Ziprasidone Cabergoline Ropinirole Dapiprazole Amitriptyline Olanzapine Alfuzosin Clozapine Norepinephrine Mirtazapine Phenylephrine Loxapine Prochlorperazine Prazosin Prazosin Imipramine Chlorpromazine Chlorpromazine Buspirone Nortriptyline Amoxapine Clonidine Doxazosin Labetalol Nicardipine Verapamil Epinephrine Thioridazine Phentolamine Ergotamine Tizanidine Tamsulosin Paroxetine Methoxamine Trimipramine Risperidone Modafinil Fenoldopam Dobutamine Quinidine Phenoxybenzamine Maprotiline Oxymetazoline Ergoloid mesylate Promethazine Carvedilol Carvedilol Doxepin Nefazodone Desipramine Terazosin Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Mephentermine Methotrimeprazine Dextroamphetamine Dextroamphetamine Phendimetrazine Periciazine Acepromazine Thioproperazine Dronedarone R450 Epicept NP-1 Sertindole Mianserin Pizotifen Silodosin Ocaperidone Droxidopa Xylometazoline Perospirone Brexpiprazole Dosulepin Etoperidone Lorpiprazole Cirazoline Synephrine Arotinolol Moxisylyte Aranidipine Pipamperone Racepinephrine Dihydroergocornine DL-Methylephedrine Indigotindisulfonic acid Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Diastolic blood pressure ( 27841878) Plasma anti-thyroglobulin levels ( 29678681) Psoriatic arthritis ( 26626624) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)	Platelet distribution width ( 32888494) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		11 interacting genes: ADRA1A AP2M1 EZR FLNC GNA11 GNAQ NOS1 PPP1R9B PRKCA SAG STAT1	26 interacting genes: ACTA1 ACTN2 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C CCKAR CCKBR CDKN2A CHRM3 DCX DRD2 LRRC7 MAPK1 PPP1CA PPP1CB PPP1CC PPP1R2 PPP1R9A PRKACA RGS2 RPS6KB1 SHANK3 TGOLN2 TIAM1
Entrez ID		147	84687
HPRD ID		00080	04506
Ensembl ID		ENSG00000170214	ENSG00000108819
Uniprot IDs		P35368	Q96SB3
PDB IDs
Enriched GO Terms of Interacting Partners?
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