CRYAA and CRYAB

Number of citations of the paper that reports this interaction (PubMedID 11700327)
27

Data Source:
HPRD (in vitro)

		CRYAA	CRYAB
Description		crystallin alpha A	crystallin alpha B
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cell Surface Postsynaptic Density Microtubule Cytoskeleton Z Disc Axon M Band Actin Filament Bundle Protein-containing Complex Dendritic Spine Perikaryon Extracellular Exosome Synaptic Membrane Cardiac Myofibril
	Molecular Function	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding	Amyloid-beta Binding Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Microtubule Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Visual Perception Negative Regulation Of Intracellular Transport Protein Refolding Negative Regulation Of Apoptotic Process Protein Stabilization Response To Stimulus	Response To Hypoxia Lens Development In Camera-type Eye Protein Folding Muscle Contraction Tubulin Complex Assembly Muscle Organ Development Multicellular Organism Aging Negative Regulation Of Gene Expression Regulation Of Cell Death Negative Regulation Of Cell Growth Microtubule Polymerization Or Depolymerization Negative Regulation Of Protein-containing Complex Assembly Response To Estradiol Negative Regulation Of Intracellular Transport Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Protein Stabilization Stress-activated MAPK Cascade Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Negative Regulation Of Amyloid Fibril Formation Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			HSF1-dependent transactivation
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 33311586 24951543) Diastolic blood pressure ( 28135244 27841878 28739976 27618452) Metabolite levels ( 23823483) Systolic blood pressure ( 27841878 28739976 27618452)	Birth weight ( 31043758) Hip circumference adjusted for BMI ( 34021172) PR interval ( 32439900)
Interacting Genes		21 interacting genes: - ALB BCL2L1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS ERG GORASP2 HSPB1 HSPB2 LALBA MIP NTAQ1 RUNX1 SDCBP SIM2 SPG21	55 interacting genes: - ACOT7 APOC2 APP ATM AVP B2M BAG3 BCL2L1 BMPR2 CAPN3 CASP3 CCL22 CCND1 CRYAA CRYBA1 CRYBB2 CRYGC CRYGD CRYGS CS DDX20 DES EPB41 FCGR2A FGF2 GFAP GORASP2 HBA1 HSPB1 HSPB2 HSPB6 HSPB8 INS KRTAP19-5 KRTAP6-1 KRTAP8-1 LALBA MDH2 MIP MRPL11 NGF PRKAG3 PRNP PSMA3 SCN5A SLC13A1 SNCA SOD1 SQSTM1 TNPO2 TRAPPC6A TTN UBE2D1 VEGFA
Entrez ID		1409	1410
HPRD ID		00427	00428
Ensembl ID		ENSG00000160202	ENSG00000109846
Uniprot IDs		A0A140G945 P02489	A0A024R3B9 P02511 V9HW27
PDB IDs		6T1R	2KLR 2N0K 2WJ7 2Y1Y 2Y1Z 2Y22 2YGD 3J07 3L1G 3SGM 3SGN 3SGO 3SGP 3SGR 3SGS 4M5S 4M5T 5VVV 6BP9
Enriched GO Terms of Interacting Partners?
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