HAPLN1 and MMP10

Number of citations of the paper that reports this interaction (PubMedID 7694569)
17

Data Source:
HPRD (in vitro)

		HAPLN1	MMP10
Description		hyaluronan and proteoglycan link protein 1	matrix metallopeptidase 10
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Synapse Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Zinc Ion Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process
Pathways		ECM proteoglycans	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases
Drugs		Hyaluronic acid	Marimastat N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID
Diseases
GWAS		Ankylosing spondylitis ( 22138694) Blood protein levels ( 30072576) Carotid intima media thickness (mean) ( 31801372) Diisocyanate-induced asthma ( 25918132) Gastroesophageal reflux disease ( 31527586) Metabolite levels ( 23823483) Prostate cancer ( 17903305) Visceral fat ( 22589738) Waist circumference ( 28552196) White matter integrity (fractional anisotropy) ( 29752348) White matter integrity (mean diffusivity) ( 29752348)	Blood protein levels ( 30072576 29875488) Multiple sclerosis ( 23412934) Prostate cancer ( 23535732)
Interacting Genes		8 interacting genes: ACAN APP MMP10 MMP2 MMP3 MMP7 MMP9 VCAN	4 interacting genes: BCAN HAPLN1 MMP9 TP53
Entrez ID		1404	4319
HPRD ID		00275	01704
Ensembl ID		ENSG00000145681	ENSG00000166670
Uniprot IDs		A0A024RAK9 P10915	P09238
PDB IDs			1Q3A 3V96 4ILW
Enriched GO Terms of Interacting Partners?
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