CRH and CRHR1

Number of citations of the paper that reports this interaction (PubMedID 9178757)
16

Data Source:
HPRD (in vivo)

		CRH	CRHR1
Description		corticotropin releasing hormone	corticotropin releasing hormone receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Varicosity Perikaryon Synapse	Endosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Plasma Membrane Neuron Projection
	Molecular Function	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Corticotropin-releasing Hormone Activity Corticotropin-releasing Hormone Receptor 1 Binding Corticotropin-releasing Hormone Receptor 2 Binding	Protein Binding G Protein-coupled Peptide Receptor Activity Corticotrophin-releasing Factor Receptor Activity Peptide Hormone Binding Corticotropin-releasing Hormone Receptor Activity Corticotropin-releasing Hormone Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Synaptic Transmission, Dopaminergic Negative Regulation Of Systemic Arterial Blood Pressure Inflammatory Response Signal Transduction Chemical Synaptic Transmission Female Pregnancy Parturition Learning Or Memory Steroid Metabolic Process Positive Regulation Of Cell Population Proliferation Associative Learning Hormone-mediated Apoptotic Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Norepinephrine Secretion Positive Regulation Of Circadian Sleep/wake Cycle, Wakefulness Positive Regulation Of Cell Death Regulation Of Serotonin Secretion Diterpenoid Metabolic Process Hypothalamus Development Negative Regulation Of Epinephrine Secretion Negative Regulation Of Luteinizing Hormone Secretion Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Immobilization Stress Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Response To Estrogen Positive Regulation Of CAMP-mediated Signaling Response To Ethanol Response To Ether Response To Pain Ion Homeostasis Response To Corticosterone Positive Regulation Of Corticotropin Secretion Positive Regulation Of Cortisol Secretion Long-term Synaptic Potentiation Positive Regulation Of Digestive System Process Negative Regulation Of Cell Death Negative Regulation Of Glucagon Secretion Cellular Response To Cocaine Cellular Response To Dexamethasone Stimulus Positive Regulation Of Calcium Ion Import Regulation Of NMDA Receptor Activity Positive Regulation Of Corticosterone Secretion Positive Regulation Of Behavioral Fear Response	Immune Response Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Female Pregnancy Parturition Hormone-mediated Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G Protein-coupled Receptor Signaling Pathway Corticotropin Secretion Cellular Response To Corticotropin-releasing Hormone Stimulus Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Corticosterone Secretion
Pathways		Class B/2 (Secretin family receptors) G alpha (s) signalling events MECP2 regulates transcription of neuronal ligands ADORA2B mediated anti-inflammatory cytokines production	Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Corticotropin D-Phenylalanine 2-aminoisobutyric acid	Corticorelin ovine triflutate
Diseases
GWAS		Adult body size ( 32376654) Coronary heart disease event reduction (statin therapy interaction) ( 22666496)	Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Alcohol consumption (drinks per week) ( 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease in APOE e4- carriers ( 25778476) Body shape index ( 34021172) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Brain morphology (MOSTest) ( 32665545) Cerebral white matter volume ( 31530798) Cortical surface area (global PC1) ( 32198502) Daytime nap ( 33568662) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) General factor of neuroticism ( 30867560) Granulocyte count ( 27863252) Head circumference (infant) ( 22504419) Headache ( 29397368) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Idiopathic pulmonary fibrosis ( 24429156) Intake of total sugars ( 31005972) Intracranial volume ( 22504418) Joint mobility (Beighton score) ( 27182965) Left-handedness ( 32989287) Leftâ€“right brain asymmetry ( 33723403) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Lymphocyte counts ( 32888494) Male-pattern baldness ( 28196072) Maximum habitual alcohol consumption ( 31151762) Medication use (antithrombotic agents) ( 31015401) Monobrow ( 27182965) Mood instability ( 31168069) Multiple system atrophy ( 27629089) Myeloid white cell count ( 27863252) Neuroticism ( 29255261) Neutrophil count ( 27863252) Parkinson's disease ( 31660654 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Primary biliary cirrhosis ( 22961000) Reticulocyte count ( 32888494) Schizophrenia ( 33169155) Subcortical brain region volumes ( 25607358) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		13 interacting genes: CRHR1 CRHR2 CYSRT1 KRT31 KRTAP1-3 KRTAP1-5 KRTAP10-8 KRTAP5-9 KRTAP9-3 LYN MDFI NBPF19 NOTCH2NLA	21 interacting genes: ARRB1 ARRB2 CALM1 CRH DLG1 DLG4 GNAI1 GNAO1 GNAQ GNAS GOPC MAGI1 MAGI2 MAGI3 MPDZ ORMDL3 PDZK1 PTPN13 SRPK1 UCN UCN3
Entrez ID		1392	1394
HPRD ID		07172	08830
Ensembl ID		ENSG00000147571	ENSG00000120088
Uniprot IDs		A0A0S2Z478 P06850	A0A024R9X9 B3SXS2 B3TIK8 G3CIS4 K9J956 P34998
PDB IDs		1GO9 1GOE 3EHT 3EHU 6P9X	2L27 3EHS 3EHT 3EHU 4K5Y 4Z9G 6P9X 6PB0
Enriched GO Terms of Interacting Partners?
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