ADORA2B and ADA

Number of citations of the paper that reports this interaction (PubMedID 11125033)
24

Data Source:
HPRD (in vivo, in vitro)

		ADORA2B	ADA
Description		adenosine A2b receptor	adenosine deaminase
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Space Lysosome Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cell Junction Dendrite Cytoplasm Neuronal Cell Body Cytoplasmic Vesicle Lumen
	Molecular Function	G Protein-coupled Adenosine Receptor Activity Protein Binding	Purine Nucleoside Binding Adenosine Deaminase Activity Protein Binding Zinc Ion Binding 2'-deoxyadenosine Deaminase Activity
	Biological Process	G Protein-coupled Adenosine Receptor Signaling Pathway Cellular Defense Response G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity JNK Cascade Excretion	Allantoin Metabolic Process Response To Hypoxia Histamine Secretion Trophectodermal Cell Differentiation Liver Development Placenta Development Germinal Center B Cell Differentiation Positive Regulation Of Germinal Center Formation Negative Regulation Of Leukocyte Migration Negative Regulation Of Mature B Cell Apoptotic Process Adenosine Catabolic Process Deoxyadenosine Catabolic Process AMP Catabolic Process Cell Adhesion Aging Purine Ribonucleoside Monophosphate Biosynthetic Process Response To Xenobiotic Stimulus Positive Regulation Of Heart Rate Positive Regulation Of B Cell Proliferation Purine Nucleotide Salvage Positive Regulation Of T Cell Differentiation In Thymus Response To Vitamin E Regulation Of Cell-cell Adhesion Mediated By Integrin T Cell Activation Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Response To Hydrogen Peroxide Purine-containing Compound Salvage Hypoxanthine Salvage Response To Morphine Positive Regulation Of Smooth Muscle Contraction DAMP Catabolic Process DATP Catabolic Process Inosine Biosynthetic Process Xanthine Biosynthetic Process Positive Regulation Of Alpha-beta T Cell Differentiation Lung Alveolus Development Peyer's Patch Development Embryonic Digestive Tract Development Negative Regulation Of Inflammatory Response Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Negative Regulation Of Thymocyte Apoptotic Process Negative Regulation Of Mucus Secretion
Pathways		Adenosine P1 receptors G alpha (s) signalling events Surfactant metabolism ADORA2B mediated anti-inflammatory cytokines production	Purine salvage
Drugs		Caffeine Theophylline Adenosine Enprofylline Defibrotide CVT-6883	Pentostatin Dipyridamole FR221647 7,8-dihydroinosine FR117016 FR236913 6-hydroxy-1,6-dihydro purine nucleoside FR-234938 FR239087 FR230513 1-Deaza-Adenosine Nebularine (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE 1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
Diseases
GWAS		HDL cholesterol levels in HIV infection ( 33109212) Immune reponse to smallpox (secreted IL-12p40) ( 22610502)	Inflammatory bowel disease ( 28067908) Serum metabolite levels ( 33031748) Ulcerative colitis ( 28067908 23128233)
Interacting Genes		7 interacting genes: ADA DCC EZR NTN1 SLC9A3R2 TPD52L2 ZNF267	12 interacting genes: ADORA1 ADORA2A ADORA2B DPP4 DRD1 GRB2 NR3C1 PIAS2 SGCD TERF2IP TINF2 WFDC12
Entrez ID		136	100
HPRD ID		15971	00038
Ensembl ID		ENSG00000170425	ENSG00000196839
Uniprot IDs		P29275	A0A0S2Z381 F5GWI4 P00813
PDB IDs			1M7M 3IAR
Enriched GO Terms of Interacting Partners?
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