TRIM40 and IFIH1

Number of citations of the paper that reports this interaction (PubMedID 29117565)
40

Data Source:
BioGRID (enzymatic study)

		TRIM40	IFIH1
Description		tripartite motif containing 40	interferon induced with helicase C domain 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm IkappaB Kinase Complex	Nucleus Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding ATP Binding Zinc Ion Binding ATP Hydrolysis Activity Identical Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Cell Growth Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Protein Catabolic Process Innate Immune Response Protein Neddylation Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of NIK/NF-kappaB Signaling	Detection Of Virus Response To Virus Protein Sumoylation Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Type III Interferon Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus MDA-5 Signaling Pathway Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Cellular Response To Virus
Pathways			DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Anger ( 24489884) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) High light scatter reticulocyte count ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494 27863252) Neuroticism ( 29255261) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Platelet count ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278)	Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 33020668) HDL cholesterol levels ( 32203549) Immunoglobulin A ( 20694011) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Psoriasis ( 25903422 20953190 25574825 23143594) Psoriasis vulgaris ( 26626624) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 27399966 26502338 28714469 19838195) Type 1 diabetes ( 21829393 25751624 19430480 17554260 30572963) Vitiligo ( 27723757 22561518) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: APP DDX58 IFIH1	9 interacting genes: APP CCDC50 GPD2 KEAP1 RNF135 TRIM40 TRIM65 USP3 ZCCHC3
Entrez ID		135644	64135
HPRD ID		15557	09507
Ensembl ID		ENSG00000204614	ENSG00000115267
Uniprot IDs		A0A1U9X8U1 Q6P9F5	Q9BYX4
PDB IDs			2RQB 3B6E 3GA3 4GL2 7JL0 7JL2
Enriched GO Terms of Interacting Partners?
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