TAAR1 and GRIK1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		TAAR1	GRIK1
Description		trace amine associated receptor 1	glutamate ionotropic receptor kainate type subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Membrane
	Molecular Function	Trace-amine Receptor Activity G Protein-coupled Receptor Activity	Glutamate Receptor Activity Ligand-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity Signaling Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	G Protein-coupled Receptor Signaling Pathway	Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Nervous System Development Central Nervous System Development Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential
Pathways		Amine ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor
Drugs		Amphetamine Lisdexamfetamine Dextroamphetamine Metamfetamine Propylhexedrine SEP-363856	Glutamic acid Butabarbital Topiramate Tezampanel
Diseases
GWAS		Compulsion score in obsessive compulsive disorder ( 32063569)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 22446040) Breast cancer ( 17903305) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Forehead morphology ( 29921221) Generalized epilepsy ( 30531953) Glucocorticoid-induced osteonecrosis ( 26265699) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Hepatocellular carcinoma ( 22807686) Hyperactive-impulsive symptoms ( 18821565) Lung cancer ( 34062886) Periodontitis (DPAL) ( 24024966) Plasma parathyroid hormone levels ( 30134803) Refractive error ( 32231278) Response to statin therapy ( 20339536) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		4 interacting genes: GRIK1 PCMT1 RNASEK SVOP	9 interacting genes: CYSLTR2 DLG4 FLNA GRIP1 HOMER1 IFNGR2 PICK1 SDCBP TAAR1
Entrez ID		134864	2897
HPRD ID		18142	00693
Ensembl ID		ENSG00000146399	ENSG00000171189
Uniprot IDs		Q96RJ0	B7Z256 B7Z3V7 E7ENK3 E7EPY9 E7EPZ0 E9PD61 P39086
PDB IDs			2ZNS 2ZNT 2ZNU 3FUZ 3FV1 3FV2 3FVG 3FVK 3FVN 3FVO 4MF3
Enriched GO Terms of Interacting Partners?
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