PPARGC1B and ZBTB9

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		PPARGC1B	ZBTB9
Description		PPARG coactivator 1 beta	zinc finger and BTB domain containing 9
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Cytosol Mediator Complex	Nucleus
	Molecular Function	Transcription Coregulator Activity RNA Binding Transcription Factor Binding Estrogen Receptor Binding Nuclear Receptor Coactivator Activity AF-2 Domain Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Ossification Regulation Of Transcription, DNA-templated Mitochondrial Transcription Actin Filament Organization Positive Regulation Of Alkaline Phosphatase Activity Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Reactive Oxygen Species Positive Regulation Of Phosphorylation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Response To Glucocorticoid Response To CAMP Bone Trabecula Formation Positive Regulation Of Cold-induced Thermogenesis	Regulation Of Transcription By RNA Polymerase II
Pathways		PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity
Drugs		Amiodarone
Diseases
GWAS		Age spots ( 29895819) Apolipoprotein A1 levels ( 32203549) Basal cell carcinoma ( 31174203) Cutaneous malignant melanoma ( 32341527) Deep white matter hyperintensities ( 32517579) Electrocardiographic traits (multivariate) ( 32602732) Facial pigmentation measurement (polar light) ( 32835660) Facial pigmentation measurement (UV light) ( 32835660) Freckles ( 29895819) HDL cholesterol levels ( 32203549) Keratinocyte cancer (MTAG) ( 31174203) Low tan response ( 29739929) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Nontraumatic osteonecrosis of the femoral head ( 32701715) Obesity-related traits ( 23251661) Tanning ( 19340012) Vitiligo ( 27723757)	Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease or systemic sclerosis ( 32024964) Diastolic blood pressure ( 27841878) Lung cancer ( 28604730)
Interacting Genes		13 interacting genes: AKT1 ESR1 ESRRG HCFC1 HNF4A PPARA SRC THRB ZBTB9 ZFP64 ZNF200 ZNF212 ZNF513	47 interacting genes: CAPN7 CBX8 CDYL2 CHURC1 CIB4 CKS1B DTNB DYRK2 EHHADH EIF4E2 GTF2E1 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP12-2 LASP1 MCM6 MDFI MORF4L1 MYBL2 NFKB1 NR3C1 PARP1 PIN1 PIN4 PPARG PPARGC1B SNIP1 SYTL4 TCEA2 TCEANC TSPYL1 TSR2 UBE2I ZBTB24 ZBTB26 ZBTB48 ZFP64 ZFY ZKSCAN5 ZNF23 ZNF407 ZNF408 ZNF417 ZNF71 ZZZ3
Entrez ID		133522	221504
HPRD ID		10594	15695
Ensembl ID		ENSG00000155846	ENSG00000213588
Uniprot IDs		B7ZM40 Q86YN6	A0A1U9X8U5 Q96C00
PDB IDs		3SP6 6D0Y
Enriched GO Terms of Interacting Partners?
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