KLHL40 and AHNAK

Number of citations of the paper that reports this interaction (PubMedID 24960163)
47

Data Source:
BioGRID (two hybrid)

		KLHL40	AHNAK
Description		kelch like family member 40	AHNAK nucleoprotein
Image
GO Annotations	Cellular Component	Cytoplasm Cul3-RING Ubiquitin Ligase Complex A Band I Band	Nucleus Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane T-tubule Vesicle Sarcolemma Costamere Cell-cell Contact Zone Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding	RNA Binding Protein Binding S100 Protein Binding Cadherin Binding Structural Molecule Activity Conferring Elasticity
	Biological Process	Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Skeletal Muscle Fiber Development Skeletal Muscle Fiber Differentiation	Regulation Of RNA Splicing Regulation Of Voltage-gated Calcium Channel Activity
Pathways
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Alzheimer's disease (late onset) ( 28714976) Blond vs. brown/black hair color ( 30531825) Body shape index ( 34021172) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cutaneous melanoma or hair colour ( 32341527) Gamma glutamyl transferase levels ( 29403010 33339817) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549 28869591) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1) ( 28166213) Monocyte percentage of white cells ( 32888494) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Serum alkaline phosphatase levels ( 31666285) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		13 interacting genes: AHNAK C7orf31 CC2D1B FSD2 LMOD3 LRRC29 MCM10 REL SAXO1 TASOR2 VDAC1 ZBED1 ZNF451	11 interacting genes: AKT1 CCDC86 CDKN2A EGFR KLHL40 MEOX2 NOL9 POT1 S100B SUMO2 XRCC4
Entrez ID		131377	79026
HPRD ID		11058	14684
Ensembl ID		ENSG00000157119	ENSG00000124942
Uniprot IDs		A8K5H9 Q2TBA0	B4DTV0 Q09666 Q9BVU3
PDB IDs		4ASC	4DRW 4FTG 4HRG
Enriched GO Terms of Interacting Partners?
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