COL11A1 and DDR1

Number of citations of the paper that reports this interaction (PubMedID 9659900)
151

Data Source:
HPRD (in vivo)

		COL11A1	DDR1
Description		collagen type XI alpha 1 chain	discoidin domain receptor tyrosine kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type XI Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Heparin Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity Metal Ion Binding Extracellular Matrix Binding Heparan Sulfate Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Tyrosine Kinase Collagen Receptor Activity Metal Ion Binding
	Biological Process	Cartilage Condensation Ossification Chondrocyte Development Proteoglycan Metabolic Process Visual Perception Sensory Perception Of Sound Extracellular Matrix Organization Collagen Fibril Organization Endodermal Cell Differentiation Tendon Development Inner Ear Morphogenesis Embryonic Skeletal System Morphogenesis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Ventricular Cardiac Muscle Tissue Morphogenesis	Regulation Of Cell Growth Regulation Of Cell-matrix Adhesion Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Embryo Implantation Lactation Negative Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Disassembly Smooth Muscle Cell Migration Positive Regulation Of Kinase Activity Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Ear Development Wound Healing, Spreading Of Cells Protein Autophosphorylation Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Alveolus Development Smooth Muscle Cell-matrix Adhesion Axon Development Neuron Projection Extension
Pathways		Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Non-integrin membrane-ECM interactions MET activates PTK2 signaling Collagen chain trimerization	Non-integrin membrane-ECM interactions
Drugs			Imatinib Fostamatinib Pralsetinib
Diseases
GWAS		Bone mineral density change response to combined chemotherapy in acute lymphoblastic leukemia ( 29266176) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Carpal tunnel syndrome ( 30833571) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Femoral neck bone mineral density ( 22504420) Glaucoma (primary angle closure) ( 22922875 27064256) Glaucoma (primary open-angle) ( 29891935) Heel bone mineral density ( 30598549) Height ( 28552196) Hip bone size ( 31053729) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Intertrochanteric region size ( 31053729) Lateral ventricle temporal horn volume ( 31530798) Open-angle glaucoma and optic cup area ( 29449654) Osteoarthritis (hip) ( 30374069) Protein quantitative trait loci ( 18464913) Spine bone size ( 31053729) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic juvenile idiopathic arthritis ( 27927641) Tinnitus ( 32970095) Triglyceride levels x loop diuretics use interaction ( 31806883) Trochanter size ( 31053729) Urate levels (BMI interaction) ( 25811787) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Age-related macular degeneration ( 23455636) Arterial stiffness index ( 31235810) Autism spectrum disorder or schizophrenia ( 28540026) HIV-1 control ( 20041166) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Malaria ( 31844061) Microalbuminuria in type 1 diabetes ( 31537649) Response to hepatitis B vaccine ( 29534301) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 30285260) Serum alkaline phosphatase levels ( 33547301) Smoking initiation (ever regular vs never regular) ( 30679032) Takayasu arteritis ( 25604533) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 20848476) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		1 interacting genes: DDR1	20 interacting genes: BEND5 BRD2 COL11A1 COL2A1 COL3A1 COL5A2 ERBB2 FRS2 MAPK6 NCK2 NUDT3 PLCG1 PTPN11 RGS2 SHC1 SNAPIN SNRNP40 TM4SF1 TTR UBQLN2
Entrez ID		1301	780
HPRD ID		00375	02678
Ensembl ID		ENSG00000060718	ENSG00000204580
Uniprot IDs		P12107 Q59HB5	A0A024RCJ0 A0A024RCL1 A0A024RCQ1 A0A0A0MSX3 Q08345 Q96T61 Q96T62
PDB IDs			3ZOS 4AG4 4BKJ 4CKR 5BVK 5BVN 5BVO 5BVW 5FDP 5FDX 6BRJ 6BSD 6FEW 6FEX 6FIL 6FIN 6FIO 6FIQ 6GWR 6HP9 6Y23 7BCM 7BE6
Enriched GO Terms of Interacting Partners?
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