TMEM18 and REEP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TMEM18	REEP4
Description		transmembrane protein 18	receptor accessory protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Integral Component Of Membrane Nuclear Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Membrane Integral Component Of Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	DNA Binding	Protein Binding Microtubule Binding
	Biological Process	Cell Migration	Nuclear Envelope Organization Mitotic Nuclear Membrane Reassembly Cell Division Endoplasmic Reticulum Tubular Network Organization
Pathways			Olfactory Signaling Pathway
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body fat percentage ( 26833246) Body mass index ( 28552196 29381148 24064335 23563607 26426971 19079260 19079261 26961502 23669352 24861553 31453325 28892062 25673413 20935630 28448500) Body mass index (adult) ( 28430825) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Breast size ( 27182965) C-reactive protein levels ( 30388399) Caffeine consumption from coffee ( 33287642) Childhood body mass index ( 33045005 26604143) Coffee consumption ( 31046077) Fasting insulin ( 34059833) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549 28869591) Heschl's gyrus morphology ( 25130324) Hip circumference ( 31453325 25673412) Hip circumference variance ( 31453325) Menarche (age at onset) ( 27182965 21102462 25231870) Metabolic syndrome ( 31589552) Obese vs. thin ( 30677029) Obesity ( 23563607) Obesity (early onset extreme) ( 20421936 23563609) Obesity (extreme) ( 30677029) Obesity-related traits ( 23251661) Parental lifespan ( 30642433) Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Refractive error ( 32231278) Response to fenofibrate (adiponectin levels) ( 23149075) Response to protease inhibitor treatment in hepatitis c (peak serum total bilirubin levels) ( 24503447) Serum uric acid levels ( 30993211) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Type 2 diabetes ( 24509480 30054458 30297969 32499647 30718926 28869590) Urate levels ( 31578528) Uric acid levels ( 22229870) Waist circumference ( 28552196 31453325 25673412) Waist circumference variance ( 31453325) Weight ( 28552196 19079260)	Frailty index ( 34431594) Hypertriglyceridemia ( 23505323)
Interacting Genes		2 interacting genes: REEP4 RETREG3	97 interacting genes: AGPAT4 BCL2L1 BET1 BIK BMP10 C14orf180 C1S C2CD2L C4orf3 CCL4L2 CLDND2 CMTM3 COMT CTSA CYB5B CYB5R3 CYP4F2 DCBLD2 DERL1 DGAT2L6 DNAJC30 ERG28 FAM241B FBXO7 FMO1 FUNDC2 GIMAP1 GYPB HSD3B7 HTATIP2 IFITM3 ITGAM LEMD1 LEMD3 LEPROTL1 LNPEP MAL2 MOSPD3 MS4A1 NCK2 ORMDL1 PEX16 PLP2 PMP22 PRAF2 RTP2 RTP4 SEC22B SELENOK SELENOM SERF1A SERF1B SERP1 SFT2D1 SFT2D2 SFXN2 SFXN3 SLC25A46 SLC30A8 SLC7A8 SMAGP SMIM1 SQLE STATH STX3 STX5 SYNJ2BP TIMM22 TMEM120B TMEM121 TMEM128 TMEM167B TMEM18 TMEM19 TMEM199 TMEM208 TMEM229B TMEM254 TMEM50A TMEM51 TMEM60 TMEM65 TMEM86A TMX2 TPRG1 TSNARE1 TSPAN2 TVP23B UBE2J1 UBIAD1 UNC50 VAMP1 VAMP4 VAPB VTI1B YIF1A YIPF4
Entrez ID		129787	80346
HPRD ID		15529	09864
Ensembl ID		ENSG00000151353	ENSG00000168476
Uniprot IDs		Q96B42	E5RGS2 Q9H6H4
PDB IDs
Enriched GO Terms of Interacting Partners?
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