COL8A1 and EFEMP2

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1103

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		COL8A1	EFEMP2
Description		collagen type VIII alpha 1 chain	EGF containing fibulin extracellular matrix protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type VIII Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Microfibril Extracellular Region Basement Membrane Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber Extracellular Vesicle
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding Protein Homodimerization Activity
	Biological Process	Angiogenesis Cell Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Endodermal Cell Differentiation Camera-type Eye Morphogenesis Epithelial Cell Proliferation	Aorta Development Elastic Fiber Assembly Aorta Smooth Muscle Tissue Morphogenesis Vascular Associated Smooth Muscle Cell Development Regulation Of Collagen Fibril Organization Positive Regulation Of Collagen Fibril Organization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Positive Regulation Of Smooth Muscle Cell-matrix Adhesion
Pathways		Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Collagen chain trimerization	Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385826 23455636) Axial length ( 24144296) Body shape index ( 34021172) Childhood ear infection ( 27182965) Cleft lip with or without cleft palate ( 28054174) Hip index ( 34021172) Nonsyndromic cleft lip with cleft palate ( 28232668) Optic cup area ( 25631615 31798171 28073927) Optic disc area ( 31798171 28073927) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Superior frontal gyrus grey matter volume ( 25335168) Vertical cup-disc ratio ( 31798171 25241763 28073927) Waist circumference adjusted for body mass index ( 34021172)	Acne (severe) ( 24927181) Adult body size ( 32376654) Birth weight ( 31043758) Body size at age 10 ( 32376654) Monocyte count ( 32888494) Retinal detachment or retinal break ( 31816047)
Interacting Genes		78 interacting genes: ADAMTSL4 ARMC5 BPIFA1 C11orf1 C19orf54 C22orf39 C9orf24 CCN3 CEP55 CIDEB COL8A2 CREB5 CYSRT1 DPEP2NB EFEMP2 FAM86C1P FBLN2 FBXO34 FRS3 GLRX3 GSC2 HOXA1 INCA1 ITGA1 ITGA2 KLHL12 KLHL20 KPRP KRT37 KRT40 KRT82 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP12-3 KRTAP13-1 KRTAP13-3 KRTAP19-2 KRTAP19-5 KRTAP19-7 KRTAP26-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 LIMS1 MAJIN NADSYN1 NBPF19 NOTCH2NLA OTX1 PLSCR3 POF1B POU4F2 PPARA RBPMS REL RGS20 RHBDD2 SLC35A2 SP4 SPATA8 SPRY4 SSC4D TRIM35 UBQLN2 UBQLN4 VAC14 WFDC5 YPEL3 ZNF774 ZNHIT1	133 interacting genes: ADAMTSL4 AMMECR1 ANAPC11 AP1M1 APEX2 AQP1 ARRDC3 ATN1 ATXN1 ATXN7 BAG6 C3 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK CDPF1 CLPP CNNM3 COL8A1 CREB5 CXCL5 CYSRT1 DGCR6 DOK7 FAM107A FAM110A FAM124B FAM74A4 FAM90A1 FBXW5 FTO FXR1 GFI1B GLRX3 HDAC4 HHEX HHIPL1 HOXA1 HPCAL1 HSD3B7 HSPA12B HSPBP1 IGFBP6 IL16 INCA1 ITGB5 KLF1 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP13-3 KRTAP19-5 KRTAP26-1 KRTAP3-2 LBX1 LCE1A LCE1C LCE1E LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LINGO1 LNX1 MDFI MEOX2 MRPL12 MXI1 NEDD4L NOS3 NR1D2 NTM NUFIP2 OTX1 P2RX7 PIDD1 PITX1 PLSCR1 PLSCR4 PROP1 PRPF31 PRR32 PTGER3 RAB40B RBAK RBP3 RBPMS RERE RHOXF2 RHPN1 RIBC2 RNF138 SGTA SGTB SHANK3 SLC16A5 SLC23A1 SLC25A48 SPACA9 SPATA24 SPATA3 SPATA8 SPRY4 STK16 TCAF1 THAP7 TLE5 TLX3 TMEM216 TP53 TRIB3 TRIM42 UBQLN1 UBQLN4 USP21 ZNF263 ZNF345 ZNF426 ZNF558 ZNF57 ZNF581 ZNF587 ZNF638 ZNF670 ZNF699 ZNF768 ZNF774 ZNF837
Entrez ID		1295	30008
HPRD ID		00372	05221
Ensembl ID		ENSG00000144810	ENSG00000172638
Uniprot IDs		P27658	A0A024R5G1 O95967 Q9H3D5
PDB IDs			2KL7
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?