TYW5 and MARS2

		TYW5	MARS2
Description		tRNA-yW synthesizing protein 5	methionyl-tRNA synthetase 2, mitochondrial
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Mitochondrial Matrix
	Molecular Function	TRNA Binding Iron Ion Binding 2-oxoglutarate-dependent Dioxygenase Activity Protein Homodimerization Activity TRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase Activity	Methionine-tRNA Ligase Activity ATP Binding
	Biological Process	Wybutosine Biosynthetic Process	TRNA Aminoacylation For Protein Translation Methionyl-tRNA Aminoacylation
Pathways		Synthesis of wybutosine at G37 of tRNA(Phe)	Mitochondrial tRNA aminoacylation
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) QT interval (sulfonylurea treatment interaction) ( 27958378) Schizophrenia ( 28991256 29483656 23974872) Sleep duration ( 30846698) Type 2 diabetes ( 25760438)	Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Idiopathic dilated cardiomyopathy ( 29495422) Morning person ( 30696823) Schizophrenia ( 25056061 29483656) Stroke ( 32693751) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		2 interacting genes: MARS2 SATB2-AS1	5 interacting genes: APP COQ10B ICA1L OGT TYW5
Entrez ID		129450	92935
HPRD ID		08232	14363
Ensembl ID		ENSG00000162971	ENSG00000247626
Uniprot IDs		A2RUC4	Q96GW9
PDB IDs		3AL5 3AL6
Enriched GO Terms of Interacting Partners?
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