COL1A1 and TMPRSS6

Number of citations of the paper that reports this interaction (PubMedID 12149247)
61

Data Source:
HPRD (in vitro)

		COL1A1	TMPRSS6
Description		collagen type I alpha 1 chain	transmembrane serine protease 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type I Trimer Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Apparatus Secretory Granule Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Space Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protease Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Skeletal System Development Ossification Blood Vessel Development Osteoblast Differentiation Intramembranous Ossification Endochondral Ossification Visual Perception Sensory Perception Of Sound Response To Xenobiotic Stimulus Response To Mechanical Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell-substrate Adhesion Protein Transport Extracellular Matrix Organization Collagen Fibril Organization Positive Regulation Of Cell Migration Response To Corticosteroid Response To Estradiol Collagen Biosynthetic Process Protein Localization To Nucleus Tooth Mineralization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Wound Healing Response To Hydrogen Peroxide Response To Peptide Hormone Skin Development Skin Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Tooth Eruption Positive Regulation Of Transcription, DNA-templated Embryonic Skeletal System Development Response To CAMP Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Cartilage Development Involved In Endochondral Bone Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Vitamin E Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Fluoride	Negative Regulation Of Transcription By RNA Polymerase II Cellular Iron Ion Homeostasis Extracellular Matrix Disassembly Collagen Catabolic Process Membrane Protein Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Iron Ion Homeostasis Self Proteolysis
Pathways		GPVI-mediated activation cascade Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) MET activates PTK2 signaling RUNX2 regulates osteoblast differentiation Collagen chain trimerization	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix
Drugs		Collagenase clostridium histolyticum Halofuginone Clove oil Vonicog Alfa Von Willebrand Factor Human
Diseases
GWAS		Blood cell traits (multivariate analysis) ( 31080455) Breast cancer ( 17903305) Heel bone mineral density ( 30598549) Keratoconus ( 33649486) Response to taxane treatment (docetaxel) ( 23006423)	Blood protein levels ( 29875488) Clinical laboratory measurements ( 27897004) Glycated hemoglobin levels ( 34059833 20858683 31213470 28898252) Hematocrit ( 29403010 32888494 28453575 27863252 28017375 19862010) Hematological and biochemical traits ( 31902109 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 29403010 19820698 32888494 28453575 19862010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693 33491795 28017375) Hepcidin levels ( 21785125) Hepcidin/ferritin ratio ( 27846281) Hepcidin/transferrin saturation ratio ( 27846281) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494 27863252) Iron levels ( 19880490) Iron status biomarkers ( 21149283 21208937 19820699 19084217) Iron status biomarkers (ferritin levels) ( 28334935 33536631 25352340) Iron status biomarkers (iron levels) ( 28334935 33536631 25352340) Iron status biomarkers (total iron binding capacity) ( 33536631) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 28334935 33536631 25352340) LDL cholesterol ( 30275531) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Mean corpuscular hemoglobin ( 23263863 29403010 32888494 19853236 28453575 20139978 27863252 28017375 19862010 28031487) Mean corpuscular hemoglobin concentration ( 23263863 29403010 32888494 28453575 20139978 27863252 28017375) Mean corpuscular volume ( 23263863 29403010 31194788 32888494 19853236 28453575 20139978 27863252 28017375 19862010) Mean spheric corpuscular volume ( 32888494) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Red blood cell count ( 32888494 27863252) Red blood cell traits ( 20927387 23935956 23222517) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Total bilirubin levels ( 29403010) Triglyceride levels ( 32203549 32154731)
Interacting Genes		40 interacting genes: ATP13A2 BARD1 BGN BMP1 BRCA1 CAPN1 CD36 CD44 CD93 CDC42 COL7A1 DCN DDR2 FGF7 FN1 HTRA1 IGFBP3 ITGA2 ITGA5 KEAP1 MAG MATN2 MCPH1 MMP2 MMP9 NID1 NID2 P4HB PAK1 PDGFA PDGFB PKD1 PRELP SPARC TGFBI THBS1 TMPRSS6 TXN UBC VWF	3 interacting genes: COL1A1 FN1 LAMA1
Entrez ID		1277	164656
HPRD ID		00362	10270
Ensembl ID		ENSG00000108821	ENSG00000187045
Uniprot IDs		P02452	Q8IU80
PDB IDs		1Q7D 2LLP 3EJH 3GXE 5CTD 5CTI 5CVA 5CVB 5K31 5OU8 5OU9
Enriched GO Terms of Interacting Partners?
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