CNR1 and SSTR5

Number of citations of the paper that reports this interaction (PubMedID 27984180)
5

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)

		CNR1	SSTR5
Description		cannabinoid receptor 1	somatostatin receptor 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Plasma Membrane Integral Component Of Plasma Membrane Actin Cytoskeleton Growth Cone Integral Component Of Mitochondrial Membrane Membrane Raft Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Presynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection
	Molecular Function	G Protein-coupled Receptor Activity Cannabinoid Receptor Activity Protein Binding Identical Protein Binding Voltage-gated Calcium Channel Activity Involved In Positive Regulation Of Presynaptic Cytosolic Calcium Levels	G Protein-coupled Receptor Activity Somatostatin Receptor Activity Peptide Binding Neuropeptide Binding
	Biological Process	Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Axonal Fasciculation Aging Response To Nutrient Memory Positive Regulation Of Neuron Projection Development Negative Regulation Of Serotonin Secretion Regulation Of Metabolic Process Sensory Perception Of Pain Positive Regulation Of Fever Generation Negative Regulation Of Fatty Acid Beta-oxidation Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Negative Regulation Of Mast Cell Activation Negative Regulation Of Dopamine Secretion Response To Nicotine Cannabinoid Signaling Pathway Response To Cocaine Glucose Homeostasis Positive Regulation Of Apoptotic Process Response To Morphine Response To Ethanol Negative Regulation Of Action Potential Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Regulation Of Insulin Secretion Negative Regulation Of Nitric-oxide Synthase Activity Regulation Of Synaptic Transmission, Glutamatergic Maternal Process Involved In Female Pregnancy Regulation Of Feeding Behavior Regulation Of Penile Erection Retrograde Trans-synaptic Signaling By Endocannabinoid Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Induction Of Synaptic Vesicle Exocytosis By Positive Regulation Of Presynaptic Cytosolic Calcium Ion Concentration	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cytokinesis Somatostatin Signaling Pathway Glucose Homeostasis Regulation Of Insulin Secretion Cellular Response To Glucocorticoid Stimulus
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		Dronabinol Nabilone Ricinoleic Acid SLV319 V24343 AVE-1625 Rimonabant Cannabidiol Propacetamol Otenabant Tetrahydrocannabivarin Medical Cannabis Nabiximols	Vapreotide Pasireotide Lanreotide Somatostatin Lutetium Lu 177 dotatate Edotreotide gallium Ga-68
Diseases
GWAS		Depression in smokers ( 30219690) Gut microbiota (functional units) ( 27694959)	Logical memory (immediate recall) in normal cognition ( 29274321) Polycystic ovary syndrome ( 25574032)
Interacting Genes		9 interacting genes: ADORA2A GNA15 GNAI1 GNAI2 GNAI3 HCRTR1 MET NSRP1 SSTR5	10 interacting genes: ADCY10 CNR1 CORT DRD2 GOPC KAT8 PDZK1 PEX5 SST SSTR1
Entrez ID		1268	6755
HPRD ID		00259	01677
Ensembl ID		ENSG00000118432	ENSG00000162009
Uniprot IDs		P21554 S5TLS4 V5KA96	P35346
PDB IDs		1LVQ 1LVR 2B0Y 2KOE 2MZ2 2MZ3 2MZA 5TGZ 5U09 5XR8 5XRA 6KPG 6KQI 6N4B
Enriched GO Terms of Interacting Partners?
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