PLK3 and RNF141

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PLK3	RNF141
Description		polo like kinase 3	ring finger protein 141
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Stack Centrosome Dendrite Neuronal Cell Body	Membrane
	Molecular Function	P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Response To Reactive Oxygen Species Protein Phosphorylation Apoptotic Process Response To Osmotic Stress Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Endomitotic Cell Cycle Response To Radiation Cytoplasmic Microtubule Organization Regulation Of Cytokinesis Negative Regulation Of Apoptotic Process Protein Kinase B Signaling Mitotic G1/S Transition Checkpoint Signaling Regulation Of Cell Division Golgi Disassembly Positive Regulation Of Intracellular Protein Transport Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Chaperone-mediated Autophagy Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia	Regulation Of Transcription, DNA-templated Protein Autoubiquitination
Pathways		TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Regulation of TP53 Activity through Phosphorylation
Drugs		Fostamatinib
Diseases
GWAS			Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		24 interacting genes: AURKA BCL2L1 CDC25C CENPU CHEK2 CIB1 HIF1A LSM5 MAP2K1 MAPK1 MFF PLK1 POU2F1 PPM1A RAD52 RNF141 RRM2 SLX4 SNCA SNCB TNS2 TP53 TRIP13 VRK1	7 interacting genes: DTX3 MAP3K1 MVK PLK3 SMURF1 TRIM24 TRIM8
Entrez ID		1263	50862
HPRD ID		04222	11509
Ensembl ID		ENSG00000173846	ENSG00000110315
Uniprot IDs		Q9H4B4	Q8WVD5
PDB IDs		4B6L	2ECN 5XEK
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?