CCR6 and DEFB4A

Number of citations of the paper that reports this interaction (PubMedID 11714836)
70

Data Source:
HPRD (in vivo, in vitro)

		CCR6	DEFB4A
Description		C-C motif chemokine receptor 6	defensin beta 4A
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Sperm Flagellum Sperm Midpiece Sperm Principal Piece Sperm Plasma Membrane	Extracellular Region Extracellular Space Golgi Lumen
	Molecular Function	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Signaling Receptor Activity	Protein Binding CCR6 Chemokine Receptor Binding Chemoattractant Activity
	Biological Process	Dendritic Cell Chemotaxis Leukocyte Migration Involved In Inflammatory Response Chemotaxis Immune Response Humoral Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Epithelial Cell Migration Calcium-mediated Signaling Isotype Switching To IgA Isotypes Cell Chemotaxis Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Chemokine-mediated Signaling Pathway Lymphocyte Migration T Cell Migration Thymocyte Migration DN2 Thymocyte Differentiation DN3 Thymocyte Differentiation Regulation Of T Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis	Chemotaxis Immune Response G Protein-coupled Receptor Signaling Pathway Killing Of Cells Of Other Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events	Beta defensins Defensins
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Basal cell carcinoma ( 31174203) Crohn's disease ( 18587394 28067908 20570966 21102463 23850713) Graves' disease ( 22922229) Inflammatory bowel disease ( 27569725 28067908 23128233) Keratinocyte cancer (MTAG) ( 31174203) Lung cancer ( 28604730) Primary biliary cholangitis ( 28425483) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Rheumatoid arthritis ( 32723749 30423114 24782177 23143596 24390342 20453841 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Social autistic-like traits ( 24133439) Triglycerides ( 24886709) Vitiligo ( 20526339 27723757)
Interacting Genes		11 interacting genes: AASS AFDN CCL20 DEFB1 DEFB103B DEFB4A EIF4A3 MARK1 QSOX1 RBM14 ZNF92	3 interacting genes: CCR6 KCNA3 TLR4
Entrez ID		1235	1673
HPRD ID		03498	03739
Ensembl ID		ENSG00000112486	ENSG00000171711
Uniprot IDs		P51684	O15263
PDB IDs		6WWZ	1E4Q 1FD3 1FD4 1FQQ 6CS9
Enriched GO Terms of Interacting Partners?
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