ISCA2 and EIF3E

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ISCA2	EIF3E
Description		iron-sulfur cluster assembly 2	eukaryotic translation initiation factor 3 subunit E
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex PML Body Eukaryotic 48S Preinitiation Complex Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3e
	Molecular Function	Iron Ion Binding Protein Binding 2 Iron, 2 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	RNA Binding Translation Initiation Factor Activity Protein Binding Cadherin Binding Protein N-terminus Binding
	Biological Process	Iron-sulfur Cluster Assembly Protein Maturation By [4Fe-4S] Cluster Transfer	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Regulation Of Translational Initiation Positive Regulation Of Translation Negative Regulation Of Translational Initiation Positive Regulation Of MRNA Binding
Pathways		Mitochondrial iron-sulfur cluster biogenesis	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Advanced glycation end-product levels ( 26915486)	Brain morphology (MOSTest) ( 32665545) Coffee consumption ( 31046077) Dupuytren's disease ( 28886342 21732829) Heel bone mineral density ( 30598549) Macular thickness ( 30535121) Male-pattern baldness ( 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007)
Interacting Genes		8 interacting genes: ANKS1A EIF3E FAM124B GEM GUCD1 NTAQ1 RNF41 SUOX	34 interacting genes: ATM C4orf19 COPS6 COPS7A COPS7B COPS8 DDX24 DRC3 EIF3C EIF3L EIF4ENIF1 EPAS1 EPN2 GPAA1 GPBP1L1 HAP1 IFIT1 ISCA2 KPRP LINC01554 MAPK1IP1L MIIP MRNIP NDRG1 NSF OGT PRRC2A RUNDC3A SHBG SMAD9 TRIM27 TRIM55 TRIM63 ZNF48
Entrez ID		122961	3646
HPRD ID		17090	03734
Ensembl ID		ENSG00000165898	ENSG00000104408
Uniprot IDs		Q86U28	P60228
PDB IDs			3J8B 3J8C 6FEC 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09
Enriched GO Terms of Interacting Partners?
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