RXFP2 and INSL3

Number of citations of the paper that reports this interaction (PubMedID 12114498)
68

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		RXFP2	INSL3
Description		relaxin family peptide receptor 2	insulin like 3
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm
	Molecular Function	G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Peptide Hormone Binding	G Protein-coupled Receptor Binding Protease Binding Signaling Receptor Binding Insulin Receptor Binding Hormone Activity Protein Binding
	Biological Process	Oocyte Maturation Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Male Gonad Development Hormone-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of CAMP-mediated Signaling	Oocyte Maturation Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Spermatogenesis Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Apoptotic Process Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Wound Healing
Pathways		G alpha (s) signalling events Relaxin receptors ADORA2B mediated anti-inflammatory cytokines production	G alpha (s) signalling events Relaxin receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Essential hypertension (time to event) ( 32589924) Glycated hemoglobin levels in type 1 diabetes ( 30674623) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 30578418) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		2 interacting genes: INSL3 RLN2	3 interacting genes: C12orf57 RBPJ RXFP2
Entrez ID		122042	3640
HPRD ID		05976	08854
Ensembl ID		ENSG00000133105	ENSG00000248099
Uniprot IDs		Q8WXD0	P51460
PDB IDs		2M96	2H8B 2K6T 2K6U
Enriched GO Terms of Interacting Partners?
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