ADD1 and SPTB

Number of citations of the paper that reports this interaction (PubMedID 8663089)
22

Data Source:
HPRD (in vitro)

		ADD1	SPTB
Description		adducin 1	spectrin beta, erythrocytic
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion F-actin Capping Protein Complex Postsynaptic Density Nuclear Body	Cytosol Plasma Membrane Spectrin Spectrin-associated Cytoskeleton Actin Cytoskeleton Cell Junction Cortical Actin Cytoskeleton Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Protein-containing Complex Cell Projection
	Molecular Function	RNA Binding Actin Binding Protein Binding Calmodulin Binding Transcription Factor Binding Spectrin Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Actin Filament Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Ankyrin Binding Actin Filament Binding
	Biological Process	Actin Cytoskeleton Organization Positive Regulation Of Protein Binding Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Cellular Response To Calcium Ion Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Adherens Junction Organization	Cytoskeleton Organization Actin Cytoskeleton Organization Actin Filament Capping
Pathways		Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes Miscellaneous transport and binding events	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases
GWAS		Coffee consumption (cups per day) ( 31837886) Household income ( 31844048) Household income (MTAG) ( 31844048) Huntington's disease progression ( 28642124) Monocyte percentage of white cells ( 32888494)	Daytime sleep phenotypes ( 27126917) Glycated hemoglobin levels ( 34059833) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Obesity-related traits ( 23251661) Pediatric areal bone mineral density (radius) ( 28181694) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Type 2 diabetes ( 31049640)
Interacting Genes		25 interacting genes: ADD2 ATP1A1 C1orf109 CALM1 CASP3 CSNK2B FGFR3 GEMIN7 HMG20A HSF2BP HSPH1 ID2 ID3 KLHL42 MAP1LC3B PRKACA PRKCA PRKCD RFX1 ROCK1 SMARCC1 SPTA1 SPTB TK1 ZDHHC17	18 interacting genes: ACTB ADD1 ANK1 AP1G1 CSRP3 DMTN ENO3 EPB41 MAPT NCAM1 RBPJ SH2D2A SNAPIN SPTA1 SPTAN1 STAT1 TULP3 YWHAQ
Entrez ID		118	6710
HPRD ID		00036	01686
Ensembl ID		ENSG00000087274	ENSG00000070182
Uniprot IDs		P35611	P11277
PDB IDs			1S35 3EDU 3F57 3KBT 3KBU 3LBX
Enriched GO Terms of Interacting Partners?
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