RFFL and MICALL1

Number of citations of the paper that reports this interaction (PubMedID 30659120)
6

Data Source:
BioGRID (enzymatic study)

		RFFL	MICALL1
Description		ring finger and FYVE like domain containing E3 ubiquitin protein ligase	MICAL like 1
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GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Lysosome Cytosol Plasma Membrane Endosome Membrane Membrane Recycling Endosome Membrane	Early Endosome Late Endosome Trans-Golgi Network Extrinsic Component Of Membrane Late Endosome Membrane Recycling Endosome Membrane
	Molecular Function	Protease Binding P53 Binding Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Small GTPase Binding Identical Protein Binding Cadherin Binding Metal Ion Binding Phosphatidic Acid Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Regulation Of Fibroblast Migration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Protein Targeting To Membrane Endocytosis Receptor-mediated Endocytosis Neuron Projection Development Endocytic Recycling Slow Endocytic Recycling Protein Localization To Endosome Plasma Membrane Tubulation Cellular Response To Nerve Growth Factor Stimulus
Pathways		Regulation of TP53 Degradation
Drugs
Diseases
GWAS		Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Night sleep phenotypes ( 27126917) QT interval ( 19305408)	Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252)
Interacting Genes		22 interacting genes: ATXN3 ATXN3L EHD1 ESPL1 MICALL1 OPTN OTUB1 OTUB2 RAB11FIP1 SFN STAM UBE2D1 UBE2D2 UBE2D3 UBE2G2 UBE2N UBE2V2 UCHL5 USP28 USP5 USP7 ZPBP2	8 interacting genes: EHD1 EHD3 RAB13 RAB1A RFFL YWHAB YWHAG ZP3
Entrez ID		117584	85377
HPRD ID		11489	11363
Ensembl ID		ENSG00000092871	ENSG00000100139
Uniprot IDs		Q8WZ73	Q8N3F8
PDB IDs		1Y02	2KSP
Enriched GO Terms of Interacting Partners?
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