AP2S1 and AAGAB

Number of citations of the paper that reports this interaction (PubMedID 26186194)
524

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology)

		AP2S1	AAGAB
Description		adaptor related protein complex 2 subunit sigma 1	alpha and gamma adaptin binding protein
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Endolysosome Membrane Intracellular Membrane-bounded Organelle Clathrin-coated Endocytic Vesicle	Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Protein Binding Clathrin Adaptor Activity	Protein Binding
	Biological Process	Intracellular Protein Transport Vesicle-mediated Transport Regulation Of Endocytosis Clathrin Coat Assembly Clathrin-dependent Endocytosis	Protein Transport
Pathways		Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Deep white matter hyperintensities ( 32517579) Low density lipoprotein cholesterol levels ( 32154731)	Allergic rhinitis ( 30013184) Asthma ( 31959851 31619474 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Bipolar disorder ( 31043756) Body shape index ( 34021172) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Keratoconus ( 33649486) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Proportion of activated microglia (midfrontal cortex) ( 30679421) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: AAGAB AP2A1 AP2B1 RNF41 TDGF1 UBC	10 interacting genes: AP1G1 AP1G2 AP1S3 AP2A1 AP2A2 AP2S1 BBS4 EIF3C HEATR1 UNC119
Entrez ID		1175	79719
HPRD ID		03762	07754
Ensembl ID		ENSG00000042753	ENSG00000103591
Uniprot IDs		M0QYZ2 M0R0N4 P53680 X6R390	Q6PD74
PDB IDs		6URI
Enriched GO Terms of Interacting Partners?
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