FTSJ3 and OAS3

Number of citations of the paper that reports this interaction (PubMedID 21903422)
143

Data Source:
BioGRID (affinity chromatography technology, pull down)

		FTSJ3	OAS3
Description		FtsJ RNA 2'-O-methyltransferase 3	2'-5'-oligoadenylate synthetase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus Preribosome, Large Subunit Precursor Preribosome, Small Subunit Precursor	Extracellular Space Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Binding Protein Binding RNA Methyltransferase Activity RRNA (uridine-2'-O-)-methyltransferase Activity RRNA (guanine) Methyltransferase Activity RNA 2'-O-methyltransferase Activity	2'-5'-oligoadenylate Synthetase Activity Double-stranded RNA Binding Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Enzyme-directed RRNA 2'-O-methylation Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA Methylation RRNA Methylation	Nucleobase-containing Compound Metabolic Process Response To Virus Positive Regulation Of Interferon-beta Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Chemokine (C-X-C Motif) Ligand 9 Production RIG-I Signaling Pathway MDA-5 Signaling Pathway Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Ribonuclease Activity Positive Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Negative Regulation Of IP-10 Production Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	Interferon gamma signaling OAS antiviral response Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Hemoglobin levels ( 32327693)	Alcohol consumption ( 21270382) Alcohol consumption (drinkers vs non-drinkers) ( 28485404) Body mass index ( 26426971) Chronic lymphocytic leukemia ( 28165464) HDL cholesterol ( 21909109) High density lipoprotein cholesterol levels ( 30718733) Hypertension ( 32709000) Low HDL-cholesterol levels ( 31006500) Myocardial infarction ( 30226566) Response to fenofibrate (adiponectin levels) ( 23149075) Right-sided colonic diverticulosis ( 31089239)
Interacting Genes		9 interacting genes: CSNK2A1 EIF2AK2 FANCG MAGEB4 OAS3 OGT SAT1 SSX2 SSX2B	5 interacting genes: DHX30 EIF6 FTSJ3 IFRD2 MAVS
Entrez ID		117246	4940
HPRD ID		17024	04519
Ensembl ID		ENSG00000108592	ENSG00000111331
Uniprot IDs		Q8IY81	Q9Y6K5
PDB IDs			4S3N
Enriched GO Terms of Interacting Partners?
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