SH2D1B and SLAMF1

Number of citations of the paper that reports this interaction (PubMedID 11689425)
35

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SH2D1B	SLAMF1
Description		SH2 domain containing 1B	signaling lymphocytic activation molecule family member 1
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GO Annotations	Cellular Component	Cytosol	External Side Of Plasma Membrane Integral Component Of Membrane Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Virus Receptor Activity Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity SH2 Domain Binding Identical Protein Binding
	Biological Process	Adaptive Immune Response Leukocyte Activation Involved In Immune Response Positive Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Positive Regulation Of Innate Immune Response	Natural Killer Cell Differentiation Natural Killer Cell Proliferation Leukocyte Chemotaxis Involved In Inflammatory Response Adaptive Immune Response Myeloid Dendritic Cell Activation Involved In Immune Response Negative Regulation Of T Cell Cytokine Production Phagocytosis Cell Adhesion Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Chemotaxis Regulation Of Vesicle Fusion Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Activated T Cell Proliferation Innate Immune Response Positive Regulation Of JNK Cascade Viral Entry Into Host Cell Regulation Of Catalytic Activity Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of CD40 Signaling Pathway Positive Regulation Of Dendritic Cell Chemotaxis Positive Regulation Of T-helper 1 Cell Cytokine Production
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Takayasu arteritis ( 25604533)	Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Memory decline ( 31985465) Microalbuminuria ( 26631737) Multiple sclerosis ( 31604244) Schizophrenia (treatment resistant) ( 22479419)
Interacting Genes		26 interacting genes: AGR2 APP AR BLK CD244 CD84 EGFR ERBB2 ERBB3 ERBB4 FCRLA GAB1 KIT LY9 MAGEB4 MAPK8IP2 MEOX2 MET NFKBID NUTM1 PRDX1 PTK2 SLAMF1 STAT4 TNK2 TRIM54	7 interacting genes: FGR FYN INPP5D PAX6 PTPN11 SH2D1A SH2D1B
Entrez ID		117157	6504
HPRD ID		12248	04603
Ensembl ID		ENSG00000198574	ENSG00000117090
Uniprot IDs		O14796	Q13291
PDB IDs		5KAZ	1D4T 1D4W 1I3Z 1KA6 1KA7 1M27 2DZF 2IE9 2IFL 2IG5
Enriched GO Terms of Interacting Partners?
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