AGAP1 and UGT1A1

		AGAP1	UGT1A1
Description		ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	UDP glucuronosyltransferase family 1 member A1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Endoplasmic Reticulum Chaperone Complex Perinuclear Region Of Cytoplasm Cytochrome Complex
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding GTP Binding Phospholipid Binding Metal Ion Binding	Retinoic Acid Binding Enzyme Inhibitor Activity Steroid Binding Glucuronosyltransferase Activity Enzyme Binding Protein Homodimerization Activity
	Biological Process	Protein Transport Regulation Of Catalytic Activity	Liver Development Bilirubin Conjugation Xenobiotic Metabolic Process Acute-phase Response Response To Nutrient Steroid Metabolic Process Estrogen Metabolic Process Response To Xenobiotic Stimulus Animal Organ Regeneration Response To Lipopolysaccharide Retinoic Acid Metabolic Process Response To Starvation Negative Regulation Of Catalytic Activity Negative Regulation Of Steroid Metabolic Process Heterocycle Metabolic Process Flavone Metabolic Process Cellular Glucuronidation Flavonoid Glucuronidation Xenobiotic Glucuronidation Biphenyl Catabolic Process Cellular Response To Ethanol Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus
Pathways			Glucuronidation Heme degradation Defective UGT1A1 causes hyperbilirubinemia
Drugs			Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Anterior thalamic nuclei volume ( 34006833) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Craniofacial microsomia ( 26853712) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Menarche (age at onset) ( 23667675) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)	Bilirubin levels ( 22085899 31801373 19419973 23371916 20639394 19414484) Bilirubin levels in extreme obesity ( 25246029) Blood metabolite levels ( 24816252) Cholelithiasis-related traits in sickle cell anemia ( 22558097) Cholesterol, total ( 24097068) Circulating cell-free DNA ( 22511988) Hair greying ( 26926045) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Low density lipoprotein cholesterol levels ( 32154731) Serum bilirubin levels in metabolic syndrome ( 30621171) Serum metabolite levels ( 23093944) Total bilirubin levels ( 29403010) Total bilirubin levels in HIV-1 infection ( 25884002)
Interacting Genes		21 interacting genes: ALPI APP ARF1 ARF6 CDC42 DNAJB3 GRB7 GUCY1A1 GUCY1B1 ITM2C RAC1 RHOA RSPH14 SLC19A3 SMN1 SP110 SRC TK1 UGT1A1 UGT1A3 ZNF534	4 interacting genes: AGAP1 COPZ1 SEC23B UGDH
Entrez ID		116987	54658
HPRD ID		16359	08933
Ensembl ID		ENSG00000157985	ENSG00000241635
Uniprot IDs		B2RZG9 Q9UPQ3 X5D293	P22309 Q5DT03
PDB IDs
Enriched GO Terms of Interacting Partners?
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