CHRNB2 and CHRNA2

Number of citations of the paper that reports this interaction (PubMedID 8906617)
15

Data Source:
HPRD (in vivo)

		CHRNB2	CHRNA2
Description		cholinergic receptor nicotinic beta 2 subunit	cholinergic receptor nicotinic alpha 2 subunit
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Integral Component Of Membrane Neuron Projection Plasma Membrane Raft Synapse Cholinergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Specialization Membrane	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Integral Component Of Membrane Neuron Projection Synapse Postsynaptic Membrane
	Molecular Function	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding Protein-containing Complex Binding	Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity
	Biological Process	Response To Hypoxia Ion Transport Calcium Ion Transport Smooth Muscle Contraction Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Visual Perception Sensory Perception Of Sound Learning Memory Locomotory Behavior Associative Learning Visual Learning Regulation Of Dopamine Secretion Sensory Perception Of Pain Vestibulocochlear Nerve Development Optic Nerve Morphogenesis Lateral Geniculate Nucleus Development Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of B Cell Proliferation Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Dopamine Secretion Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Social Behavior Regulation Of Dopamine Metabolic Process B Cell Activation Response To Cocaine Regulation Of Circadian Sleep/wake Cycle, REM Sleep Regulation Of Membrane Potential Response To Ethanol Negative Regulation Of Action Potential Regulation Of Dendrite Morphogenesis Nervous System Process Cognition Membrane Depolarization Regulation Of Synapse Assembly Excitatory Postsynaptic Potential Synaptic Transmission Involved In Micturition Acetylcholine Receptor Signaling Pathway Response To Acetylcholine	Ion Transport Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Ion Transmembrane Transport Response To Nicotine Regulation Of Membrane Potential Nervous System Process Excitatory Postsynaptic Potential
Pathways		Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		Nicotine Butabarbital Methadone Dextromethorphan Atropine Mecamylamine Scopolamine Isoflurane Ethanol Physostigmine Decamethonium Varenicline Pozanicline RPI-78M Rivanicline Epibatidine Cytisine	Nicotine Butabarbital Carbamoylcholine Metocurine iodide Fluoxetine Gallamine triethiodide Dextromethorphan Cisatracurium Mecamylamine Procaine Rocuronium Atracurium besylate Ethanol Doxacurium Tubocurarine Mivacurium Decamethonium Metocurine Pancuronium Pipecuronium Vecuronium RPI-78M Epibatidine Hexamethonium
Diseases
GWAS		Nicotine dependence ( 28440896) Smoking behaviour (cigarettes smoked per day) ( 30679032)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Autism spectrum disorder or schizophrenia ( 28540026) Cannabis use disorder ( 33096046 31209380) Lung cancer ( 28604730) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Schizophrenia ( 29483656) Smoking status (current vs mixed) ( 33082346) Smoking status (current vs never) ( 33082346)
Interacting Genes		3 interacting genes: CHRNA2 CHRNA4 CRELD2	2 interacting genes: CHRNB2 CHRNB4
Entrez ID		1141	1135
HPRD ID		00335	00332
Ensembl ID		ENSG00000160716	ENSG00000120903
Uniprot IDs		P17787 Q5SXY3	Q15822
PDB IDs		2GVT 2K58 2K59 2KSR 2LM2 5KXI 6CNJ 6CNK 6UR8 6USF	5FJV
Enriched GO Terms of Interacting Partners?
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