MAP4K5 and ZNF440

Number of citations of the paper that reports this interaction (PubMedID 20936779)
88

Data Source:
BioGRID (two hybrid)

		MAP4K5	ZNF440
Description		mitogen-activated protein kinase kinase kinase kinase 5	zinc finger protein 440
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Protein Serine Kinase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Intracellular Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways			Generic Transcription Pathway
Drugs		Fostamatinib
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Cognitive performance ( 20125193) Dupuytren's disease ( 28886342) Heel bone mineral density ( 30598549) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Hip index ( 34021172) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean platelet volume ( 32888494) Periodontal disease-related phenotype (Socransky) ( 24347629) Red blood cell count ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) White blood cell count ( 32888494)
Interacting Genes		14 interacting genes: ABL1 BCR COPS5 CRK CRKL GRB2 HCK IFT88 NEDD4 SETDB1 SMURF1 TANK TRAF2 ZNF440	36 interacting genes: CARD10 CCDC136 CCNDBP1 CLK2 CSNK2A1 CYSRT1 FHL5 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP4-4 KRTAP5-7 KRTAP5-9 KRTAP9-3 LMNA MAP4K5 MDFI MID2 MTUS2 NBPF19 NOTCH2NLA PAX9 PJA1 STX1A TRAF1 XBP1 ZNF330
Entrez ID		11183	126070
HPRD ID		05374	11718
Ensembl ID		ENSG00000012983	ENSG00000171295
Uniprot IDs		B3KWC4 Q9Y4K4	Q8IYI8
PDB IDs
Enriched GO Terms of Interacting Partners?
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