TOPBP1 and SMARCAD1

Number of citations of the paper that reports this interaction (PubMedID 28063255)
19

Data Source:
BioGRID (two hybrid, pull down)

		TOPBP1	SMARCAD1
Description		DNA topoisomerase II binding protein 1	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
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GO Annotations	Cellular Component	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Microtubule Organizing Center Plasma Membrane Actin Cytoskeleton Nuclear Body PML Body Intracellular Membrane-bounded Organelle	Heterochromatin Nucleus Nucleoplasm Site Of Double-strand Break Nuclear Replication Fork
	Molecular Function	DNA Binding Protein Binding Protein C-terminus Binding Identical Protein Binding	DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA ATP Hydrolysis Activity Ubiquitin Binding ATP-dependent Chromatin Remodeler Activity
	Biological Process	DNA Metabolic Process DNA Replication Initiation DNA Repair Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Mitotic DNA Replication Checkpoint Signaling	Regulation Of DNA Recombination DNA Double-strand Break Processing Chromatin Remodeling DNA Duplex Unwinding Chromosome Separation Histone H3 Deacetylation Histone H4 Deacetylation
Pathways		HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Iron status biomarkers ( 19084217)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Capecitabine sensitivity ( 22864933) Colorectal cancer or advanced adenoma ( 30510241) Cortical surface area (MOSTest) ( 32665545) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549 28869591) Low susceptibility to hepatitis C infection ( 31206233) Menarche (age at onset) ( 25231870) QT interval ( 24952745 29874175) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728 28604732 23666239) Type 2 diabetes ( 30297969)
Interacting Genes		34 interacting genes: ABL1 AKT1 ATM BLM BMPR2 BRIP1 CDC45 CHEK1 CIP2A CLSTN1 E2F1 ESR1 FHL3 GINS1 HUS1 NPHP3 PML POLE PPHLN1 PPP1CC RAD1 RAD9A RAI1 RBBP8 RHNO1 SF3B2 SMARCAD1 TBC1D4 TCFL5 TEX11 TICRR TOP2B UBR5 ZBTB17	5 interacting genes: PCNA SLC39A8 SUMO2 TOPBP1 TRIM28
Entrez ID		11073	56916
HPRD ID		09678	11586
Ensembl ID		ENSG00000163781	ENSG00000163104
Uniprot IDs		A0AV47 A7E2X7 Q05BV8 Q92547	Q9H4L7
PDB IDs		1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO 6RML 6RMM	6H3A 6QU1
Enriched GO Terms of Interacting Partners?
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