CHD3 and TNFRSF14

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CHD3	TNFRSF14
Description		chromodomain helicase DNA binding protein 3	TNF receptor superfamily member 14
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome NuRD Complex PML Body Centriolar Satellite	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding DNA Helicase Activity RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding ATP Hydrolysis Activity Double-stranded DNA Helicase Activity ATP-dependent Chromatin Remodeler Activity	Virus Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding Cytokine Binding Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Assembly Or Disassembly Chromatin Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Spindle Organization Centrosome Cycle DNA Duplex Unwinding	Adaptive Immune Response Positive Regulation Of Cytokine Production Involved In Immune Response Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Innate Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Viral Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Negative Regulation Of Adaptive Immune Memory Response Positive Regulation Of T Cell Migration
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS	Costimulation by the CD28 family Costimulation by the CD28 family TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Ischemic stroke ( 26089329) Macular thickness ( 30535121) Prostate cancer ( 29892016) Refractive error ( 32231278) Stroke ( 26089329)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Autoimmune thyroid disease ( 32581359) Body mass index ( 26426971) Celiac disease ( 20190752) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 28067908) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 28445677) Primary sclerosing cholangitis ( 23603763) Rheumatoid arthritis ( 24449572 30423114 18794853 24390342 20453842) Ulcerative colitis ( 28067908 26398853 23128233 21297633)
Interacting Genes		100 interacting genes: ACTR1B ADH5 AIMP2 ATP5IF1 BARD1 BCL6 BHLHE40 C4orf17 CASP6 CASP8 CBX4 CHMP2A CPE CRCT1 CREB1 CREBBP CSTF2 CTBP1 CTTN CUL2 ENTR1 FABP4 FBP2 FUBP1 GADD45A GIT1 GPS2 GSK3B HABP4 HDAC2 HSD17B10 HSPH1 HTT IK IKZF1 IKZF3 IMMT IVNS1ABP KIF15 KPNA2 KPNB1 LRIF1 LUC7L2 MAFG MAN2A2 MX1 MYB NEFL NR1H2 NR4A1 PAICS PCMT1 PIAS1 PIAS4 PLK4 PRG2 PRPF40A PSME1 PTN PTPRS PUF60 RAD51 RETREG2 RGS2 RIF1 RPL29 SAFB SAT1 SATB1 SERBP1 SERF2 SGSM2 SIRT6 SKIL SLC27A6 SPOP SRRT SUMO1 SUMO2 TAL1 TCERG1 THOC7 TNFRSF14 TNNT1 TP53 TP73 TRIM28 TRIM54 TSC22D1 TSPAN6 TTR TXNDC9 UBA3 UBC UBE2I UROD VIM XRCC4 YAE1 ZHX1	39 interacting genes: A2M ANGPTL7 APP BTLA CD160 CEP126 CHD3 DGKD DRAP1 DYNLL1 ENO1 ESR1 HDAC3 HDAC4 IMPA2 ITFG1 LTA MASP2 MBTPS1 NDST2 NDUFS2 NID2 NRIP1 POLR1A RAD21 RPL22 SERPINA4 SRM TNFSF13 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF5 UBQLN4 UNC93A VIM WDR73 ZBTB48
Entrez ID		1107	8764
HPRD ID		09071	04122
Ensembl ID		ENSG00000170004	ENSG00000157873
Uniprot IDs		B3KWV4 Q12873 Q2TAZ1	A0A024R052 Q92956
PDB IDs			1JMA 2AW2 4FHQ 4RSU 5T2Q 5T2R 6NG3
Enriched GO Terms of Interacting Partners?
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