METAP2 and S100A4

Number of citations of the paper that reports this interaction (PubMedID 11994292)
17

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		METAP2	S100A4
Description		methionyl aminopeptidase 2	S100 calcium binding protein A4
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Extracellular Region Extracellular Space Nucleus Neuron Projection Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	RNA Binding Aminopeptidase Activity Protein Binding Metalloexopeptidase Activity Metal Ion Binding Metalloaminopeptidase Activity	RNA Binding Actin Binding Calcium Ion Binding Protein Binding Identical Protein Binding Transition Metal Ion Binding Calcium-dependent Protein Binding RAGE Receptor Binding
	Biological Process	Protein Processing Peptidyl-methionine Modification N-terminal Protein Amino Acid Modification Protein Initiator Methionine Removal	Epithelial To Mesenchymal Transition Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways		Inactivation, recovery and regulation of the phototransduction cascade
Drugs		Methionine Nitroxoline 3,5,6,8-Tetramethyl-N-Methyl Phenanthrolinium Fumagillin D-Methionine N'-(2s,3r)-3-Amino-4-Cyclohexyl-2-Hydroxy-Butano-N-(4-Methylphenyl)Hydrazide (2R,3R,4S,5R,6E)-3,4,5-Trihydroxy-N-[(3S,6R)-6-hydroxy-2-oxo-3-azepanyl]-2-methoxy-8,8-dimethyl-6-nonenamide tert-butanol (2s,3r)-3-Amino-2-Hydroxy-5-(Ethylsulfanyl)Pentanoyl-((S)-(-)-(1-Naphthyl)Ethyl)Amide Ovalicin PPI-2458 5-BROMO-2-{[(4-CHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID 5-METHYL-2-[(PHENYLSULFONYL)AMINO]BENZOIC ACID 2-[(PHENYLSULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID 2-[({2-[(1Z)-3-(DIMETHYLAMINO)PROP-1-ENYL]-4-FLUOROPHENYL}SULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID N'-((2S,3R)-3-AMINO-2-HYDROXY-5-(ISOPROPYLSULFANYL)PENTANOYL)-N-3-CHLOROBENZOYL HYDRAZIDE 3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-2-METHYLBENZOIC ACID TNP-470	Trifluoperazine Copper
Diseases
GWAS		Blood protein levels ( 30072576) C-reactive protein levels ( 30388399) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 27863252) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Metabolite levels ( 23823483) Reticulocyte count ( 32888494)	Blood protein levels ( 29875488) Pulse pressure ( 30578418)
Interacting Genes		14 interacting genes: APP CALM1 CDC42 EIF2AK2 EIF2S3 FBXL17 HMGA1 MAPK1 MAPK3 OGT PJA1 RAC1 S100A4 YWHAE	28 interacting genes: ACTA1 ANXA2 BAG6 CCN3 CEP20 EGFR FCGR3A HSPB1 MDM2 METAP2 MYH10 MYH2 MYH4 MYH9 PPFIBP1 RHOU S100A1 S100B S100P SEPTIN2 SEPTIN6 SEPTIN7 SMAD3 SRPK2 TP53 TPM2 TPM3 UNC119
Entrez ID		10988	6275
HPRD ID		03522	15914
Ensembl ID		ENSG00000111142	ENSG00000196154
Uniprot IDs		A0A140VJE3 F8VQZ7 P50579	P26447
PDB IDs		1B59 1B6A 1BN5 1BOA 1KQ0 1KQ9 1QZY 1R58 1R5G 1R5H 1YW7 1YW8 1YW9 2ADU 2EA2 2EA4 2GA2 2OAZ 5CLS 5D6E 5D6F 5JFR 5JHU 5JI6 5LYW 5LYX 6QED 6QEF 6QEG 6QEH 6QEI 6QEJ 7A12 7A13 7A14 7A15 7A16	1M31 2LNK 2MRD 2Q91 3C1V 3CGA 3KO0 3M0W 3ZWH 4CFQ 4CFR 4ETO 4HSZ 5LPU 6T58
Enriched GO Terms of Interacting Partners?
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