ADIRF and IL18

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ADIRF	IL18
Description		adipogenesis regulatory factor	interleukin 18
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Extracellular Exosome	Extracellular Region Extracellular Space Cytosol
	Molecular Function	Molecular_function Protein Binding	Cytokine Activity Protein Binding Interleukin-18 Receptor Binding
	Biological Process	Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Radiation Cellular Response To Cisplatin Regulation Of Response To Drug	MAPK Cascade Angiogenesis Inflammatory Response Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Natural Killer Cell Activation Regulation Of Cell Adhesion Sleep Lipopolysaccharide-mediated Signaling Pathway Activation Of Protein Kinase B Activity Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Tissue Remodeling Interleukin-18-mediated Signaling Pathway T-helper 1 Type Immune Response Type 2 Immune Response Positive Regulation Of Activated T Cell Proliferation Neutrophil Activation Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Cholesterol Homeostasis Positive Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of NK T Cell Proliferation Positive Regulation Of Protein Kinase B Signaling Triglyceride Homeostasis Cellular Response To Organic Cyclic Compound Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Neuroinflammatory Response Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of T-helper 1 Cell Cytokine Production
Pathways		Transcriptional regulation of white adipocyte differentiation	Interleukin-1 processing Pyroptosis Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling Purinergic signaling in leishmaniasis infection
Drugs
Diseases
GWAS			Blood protein levels in cardiovascular risk ( 28369058) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 27989323 31584380) Protein quantitative trait loci ( 18464913)
Interacting Genes		3 interacting genes: GSK3B IL18 RPS6KA6	9 interacting genes: ADIRF CASK CASP1 CASP3 CASP4 IL18BP IL18R1 IL18RAP IL1RL2
Entrez ID		10974	3606
HPRD ID		16575	02976
Ensembl ID		ENSG00000148671	ENSG00000150782
Uniprot IDs		Q15847 Q5TBU5	A0A024R3E0 Q14116
PDB IDs			1J0S 2VXT 3F62 3WO2 3WO3 3WO4 4EEE 4EKX 4HJJ 4R6U 4XFS 4XFT 4XFU
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?