C11orf58 and MBTPS1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		C11orf58	MBTPS1
Description		chromosome 11 open reading frame 58	membrane bound transcription factor peptidase, site 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component	Golgi Membrane Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Stack Integral Component Of Membrane
	Molecular Function	Molecular_function	Serine-type Endopeptidase Activity
	Biological Process	Biological_process	Proteolysis Lysosome Organization Cholesterol Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Membrane Protein Intracellular Domain Proteolysis Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Regulation Of Cholesterol Biosynthetic Process Regulation Of Vesicle-mediated Transport
Pathways			Regulation of cholesterol biosynthesis by SREBP (SREBF) ATF6 (ATF6-alpha) activates chaperones Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) CREB3 factors activate genes CREB3 factors activate genes Post-translational protein phosphorylation Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS		Chronotype ( 30696823) Coronary artery disease ( 33020668) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Lumbar spine bone mineral density ( 29499414) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494) Serum alkaline phosphatase levels ( 33547301)	Iris color (a* coordinate) ( 30895295) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872)
Interacting Genes		16 interacting genes: A2M CEP126 EEF1G FBN3 MBTPS1 POLR2C PTN RNF19A RPLP1 SEMA5B SF3B1 SHC1 SLC44A1 SNCAIP TRA2A ZBTB48	10 interacting genes: ATF6B BDNF BIRC3 C11orf58 CANX CDK2AP2 SPHK1 TNFRSF14 TNFSF11 ZBED8
Entrez ID		10944	8720
HPRD ID		18069	04522
Ensembl ID		ENSG00000110696	ENSG00000140943
Uniprot IDs		O00193	Q14703
PDB IDs
Enriched GO Terms of Interacting Partners?
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