LYVE1 and THSD7A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LYVE1	THSD7A
Description		lymphatic vessel endothelial hyaluronan receptor 1	thrombospondin type 1 domain containing 7A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Extracellular Exosome	Extracellular Region Plasma Membrane Integral Component Of Membrane Cell Projection
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Hyaluronic Acid Binding Signaling Receptor Activity	Protein Binding
	Biological Process	Glycosaminoglycan Catabolic Process Cell-matrix Adhesion Response To Wounding Anatomical Structure Morphogenesis	Angiogenesis Cell Differentiation Actin Cytoskeleton Reorganization
Pathways		Hyaluronan uptake and degradation	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Age at voice drop ( 27182965) Alzheimer's disease (APOE e4 interaction) ( 25778476) Bipolar disorder ( 31043756) Cataracts (operation) ( 31816047) Coronary artery disease ( 29472232) Dental caries (decayed, missing and filled teeth) ( 31533690) End-stage kidney disease ( 31178898) Facial emotion recognition (angry faces) ( 28608620) Glaucoma ( 31959993 30054594) Glaucoma (primary open-angle) ( 33627673 29891935) Household income (MTAG) ( 31844048) Idiopathic dilated cardiomyopathy ( 29495422) Intraocular pressure ( 29785010 31959993) Iron status biomarkers (total iron binding capacity) ( 28334935) Lead levels in blood ( 25820613) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Medication use (antiglaucoma preparations and miotics) ( 31015401) Refractive error ( 32231278) Response to antiepileptic mood-stabilizing treatment in bipolar disorder ( 32627186) Resting-state electroencephalogram vigilance ( 29703947) Systolic blood pressure x educational attainment (some college) interaction (2df) ( 32372009) Tourette syndrome ( 22889924)
Interacting Genes		26 interacting genes: AIG1 AQP10 CLCN7 CYSRT1 EMP3 KRT34 KRTAP10-3 KRTAP10-8 KRTAP12-3 KRTAP6-2 KRTAP9-2 NBPF19 NINJ2 NOTCH2NLA NRSN1 PDGFB PIGF SERP2 SLC30A2 SLC38A7 SLC41A2 THSD7A THSD7B UBE2J1 VEGFA YIPF6	15 interacting genes: - AQP6 ARL13B ASAP2 CD33 COMT ELOVL5 GOLM1 HSD17B13 LHFPL1 LYVE1 SCN3B SKIL TMUB2 VMA21
Entrez ID		10894	221981
HPRD ID		05753	19401
Ensembl ID		ENSG00000133800	ENSG00000005108
Uniprot IDs		B2R672 Q9Y5Y7	Q9UPZ6
PDB IDs
Enriched GO Terms of Interacting Partners?
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