TRAF3IP2 and FHL3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		TRAF3IP2	FHL3
Description		TRAF3 interacting protein 2	four and a half LIM domains 3
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytoplasmic Vesicle	Stress Fiber Nucleus Focal Adhesion Z Disc
	Molecular Function	Signaling Receptor Binding Protein Binding Ubiquitin Protein Ligase Activity	Transcription Coregulator Activity Actin Binding Protein Binding Metal Ion Binding
	Biological Process	Establishment Of T Cell Polarity B Cell Homeostasis B Cell Apoptotic Process Kidney Development Positive Regulation Of Defense Response To Virus By Host Leukocyte Activation Involved In Inflammatory Response Transitional Two Stage B Cell Differentiation B Cell Affinity Maturation Eosinophil Mediated Immunity Protein Import Into Nucleus Inflammatory Response Humoral Immune Response Heart Development Response To Xenobiotic Stimulus Signal Transduction Involved In Regulation Of Gene Expression CD40 Signaling Pathway T Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Intracellular Signal Transduction Interleukin-17A-mediated Signaling Pathway Type 2 Immune Response Neutrophil Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Skin Development MRNA Stabilization Lymph Node Development Spleen Development Mucus Secretion Protein K63-linked Ubiquitination T-helper 17 Type Immune Response Interleukin-17-mediated Signaling Pathway Protein Localization To P-body Eosinophil Homeostasis	Regulation Of Transcription, DNA-templated Muscle Organ Development Actin Cytoskeleton Organization
Pathways
Drugs
Diseases
GWAS		Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Inflammatory bowel disease ( 28067908 23128233) Inflammatory skin disease ( 25574825) Intraocular pressure ( 29617998) Psoriasis ( 25903422 20953188 20953190 25574825 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624 20953186) Refractive error ( 32231278) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 28067908)	Coronary artery disease ( 29212778 33020668) Pulse pressure ( 30578418)
Interacting Genes		23 interacting genes: CD40 CHUK FHL3 GOLGA2 HSD17B10 IKBKB IKBKG MAP3K7 MDFI MRPL28 RIMBP3 STK16 TBK1 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIM55 TRIM63 TRIP6 UBC UBE2V1	182 interacting genes: A1CF ACTB ADAM15 ADAMTSL4 AIMP2 AMBP ANKHD1 ARHGEF10 ARID5A ASCL4 BARX2 C1orf94 C9orf116 CASS4 CBX8 CCDC198 CCND3 CDC25B CDC42EP1 CDKN1A CDKN2D CHEK2 CLCN2 CNNM3 CNOT7 CORO1A CREB5 CRIP3 CRYBA2 CSF1 CTBP2 CYSRT1 DCDC2B DLGAP4 DMRT3 DUX4L9 E2F8 EFCAB12 EIF4EBP2 EPHA10 EPM2AIP1 ERBB3 EXOSC1 EXOSC5 FADS6 FAM110A FAM126A FAM222B FAM71C FAM90A1 FBXL18 FHL2 FOS FOSL2 FOXN4 GATA1 GATA2 GCM2 GUCD1 HAPLN2 HIPK1 HOXA1 HSF2BP HYAL2 IHO1 IKZF3 ITGA7 ITGB5 KANK2 KIDINS220 KIRREL2 KLF12 KLF3 KLF8 KPRP KRTAP12-1 KRTAP12-2 KTI12 LASP1 LATS2 LHB LMO2 LMO4 LNX1 LNX2 MAPK1 MED15 MMP14 MORF4L1 MPZL1 MRM3 MRPL27 MRRF MSRB3 MTA1 MTUS2 MYBPC1 MYBPHL MYCBP2 MYOZ3 MYPOP MZF1 NDUFAB1 NFKBIB NPRL3 ODF3B P4HA2 PAK5 PATL1 PHC2 PHF21A PIAS1 PKP2 PLEKHF2 PLEKHG4B POLR1H PPIG PPP1R32 PRR35 PRR5L PTPN6 QKI QRICH1 RAB40B RAD21 RASL12 RBM42 RFX3 RFX6 RHEBL1 RSPH14 RYBP SAP30BP SAXO1 SBF2 SDCBP SH3GLB2 SHE SLAIN1 SLC25A46 SLC44A3 SLU7 SMAD2 SMAD3 SMAD4 SNRPB SNRPC SNRPG SPATA8 SREBF2 SRF SRGN SUPT5H TBC1D22B THAP7 THEG TLE5 TMEM108 TMEM14B TMSB4X TMX3 TOPBP1 TRAF3IP2 TRIM27 TRIP6 TRO TSGA10IP TTLL10 TUBA3E TYK2 TYMSOS UBE2I UBE2Q1 VWC2L WDR25 WNK1 YPEL3 ZCCHC14 ZFP36 ZNF417 ZNF512B ZNF587
Entrez ID		10758	2275
HPRD ID		06129	09101
Ensembl ID		ENSG00000056972	ENSG00000183386
Uniprot IDs		O43734	Q13643 Q96C98
PDB IDs			1WYH 2CUQ 2EHE
Enriched GO Terms of Interacting Partners?
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