MASP2 and TNFRSF14

		MASP2	TNFRSF14
Description		MBL associated serine protease 2	TNF receptor superfamily member 14
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Complement Component C4b Binding Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Calcium-dependent Protein Binding	Virus Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding Cytokine Binding Ubiquitin Protein Ligase Binding
	Biological Process	Complement Activation, Lectin Pathway Proteolysis Complement Activation, Classical Pathway	Adaptive Immune Response Positive Regulation Of Cytokine Production Involved In Immune Response Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Innate Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Viral Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Negative Regulation Of Adaptive Immune Memory Response Positive Regulation Of T Cell Migration
Pathways			Costimulation by the CD28 family Costimulation by the CD28 family TNFs bind their physiological receptors
Drugs		beta-Hydroxyasparagine
Diseases
GWAS		Beard thickness ( 26926045) Body mass index ( 29273807) Eosinophil percentage of white cells ( 32888494) Male-pattern baldness ( 28196072)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Autoimmune thyroid disease ( 32581359) Body mass index ( 26426971) Celiac disease ( 20190752) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 28067908) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 28445677) Primary sclerosing cholangitis ( 23603763) Rheumatoid arthritis ( 24449572 30423114 18794853 24390342 20453842) Ulcerative colitis ( 28067908 26398853 23128233 21297633)
Interacting Genes		5 interacting genes: C4A FCN2 MBL2 SERPING1 TNFRSF14	39 interacting genes: A2M ANGPTL7 APP BTLA CD160 CEP126 CHD3 DGKD DRAP1 DYNLL1 ENO1 ESR1 HDAC3 HDAC4 IMPA2 ITFG1 LTA MASP2 MBTPS1 NDST2 NDUFS2 NID2 NRIP1 POLR1A RAD21 RPL22 SERPINA4 SRM TNFSF13 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF5 UBQLN4 UNC93A VIM WDR73 ZBTB48
Entrez ID		10747	8764
HPRD ID		05484	04122
Ensembl ID		ENSG00000009724	ENSG00000157873
Uniprot IDs		O00187	A0A024R052 Q92956
PDB IDs		1Q3X 1SZB 1ZJK 3TVJ 4FXG 5JPM	1JMA 2AW2 4FHQ 4RSU 5T2Q 5T2R 6NG3
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?