NUDC and PAFAH1B1

Number of citations of the paper that reports this interaction (PubMedID 9601647)
35

Data Source:
HPRD (in vivo, in vitro)

		NUDC	PAFAH1B1
Description		nuclear distribution C, dynein complex regulator	platelet activating factor acetylhydrolase 1b regulatory subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Spindle Cytosol Microtubule Midbody Mitotic Spindle	Astral Microtubule Kinetochore Nuclear Envelope Centrosome Cytosol Kinesin Complex Microtubule Associated Complex Cytoplasmic Microtubule Cell Cortex 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Cell Leading Edge Motile Cilium Nuclear Membrane Stereocilium Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Central Region Of Growth Cone Axon Cytoplasm
	Molecular Function	Protein Binding Cadherin Binding Unfolded Protein Binding	Protein Binding Microtubule Binding Heparin Binding Dynactin Binding Identical Protein Binding Phospholipase Binding Dynein Intermediate Chain Binding Protein Heterodimerization Activity Microtubule Plus-end Binding Phosphoprotein Binding Dynein Complex Binding
	Biological Process	Protein Folding Mitotic Spindle Organization Mitotic Metaphase Plate Congression Cell Division	Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Ameboidal-type Cell Migration Acrosome Assembly Neuron Migration Positive Regulation Of Cytokine-mediated Signaling Pathway Microtubule-based Process Nuclear Migration Chemical Synaptic Transmission Germ Cell Development Neuroblast Proliferation Learning Or Memory Retrograde Axonal Transport Adult Locomotory Behavior Protein Secretion Negative Regulation Of Neuron Projection Development Lipid Catabolic Process Stem Cell Division Transmission Of Nerve Impulse Corpus Callosum Morphogenesis Hippocampus Development Layer Formation In Cerebral Cortex Cerebral Cortex Neuron Differentiation Cerebral Cortex Development Actin Cytoskeleton Organization Microtubule Organizing Center Organization Osteoclast Development Reelin-mediated Signaling Pathway Positive Regulation Of Embryonic Development Establishment Of Planar Polarity Of Embryonic Epithelium Regulation Of GTPase Activity Cortical Microtubule Organization Positive Regulation Of Axon Extension Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Platelet Activating Factor Metabolic Process Vesicle Transport Along Microtubule Brain Morphogenesis Neuromuscular Process Controlling Balance Microtubule Sliding Nuclear Membrane Disassembly Establishment Of Centrosome Localization Maintenance Of Centrosome Location Auditory Receptor Cell Development Positive Regulation Of Dendritic Spine Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Cochlea Development Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation RND2 GTPase cycle	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Apolipoprotein A1 levels ( 33730874) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Plateletcrit ( 27863252)	Adverse response to drug ( 30420678) Anxiety ( 33859377) Depression ( 33859377) Mean platelet volume ( 32888494) Neurociticism ( 29500382) Neuroticism ( 27089181) Self-reported tiredness ( 28194004)
Interacting Genes		8 interacting genes: ACD HPCA OGT PAFAH1B1 PLK1 POT1 TINF2 TUBE1	23 interacting genes: CLIP1 CSNK2A1 DAB1 DCTN1 DCTN2 DCX DNAI1 DYNC1H1 FBXO7 HSPH1 KARS1 KATNA1 KATNB1 MAP1B MAP2 NDE1 NDEL1 NUDC PAFAH1B2 PAFAH1B3 PDE4D TNIK TUBA1A
Entrez ID		10726	5048
HPRD ID		10122	03329
Ensembl ID		ENSG00000090273	ENSG00000007168
Uniprot IDs		Q9Y266	A0A6Q8PFT2 A0A6Q8PFU3 P43034
PDB IDs		3QOR
Enriched GO Terms of Interacting Partners?
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