PMVK and DDIT4L

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PMVK	DDIT4L
Description		phosphomevalonate kinase	DNA damage inducible transcript 4 like
Image			No pdb structure
GO Annotations	Cellular Component	Peroxisome Cytosol Membrane Extracellular Exosome	Cytoplasm
	Molecular Function	Phosphomevalonate Kinase Activity Protein Binding ATP Binding	Protein Binding
	Biological Process	Cholesterol Biosynthetic Process Sterol Biosynthetic Process Phosphorylation Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Response To Cholesterol	Negative Regulation Of Signal Transduction
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015 22544366) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Inflammatory bowel disease ( 27569725) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Prostate cancer ( 23535732)	Alcohol consumption (drinks per week) ( 30643258) Nose size ( 27182965)
Interacting Genes		4 interacting genes: DDIT4L MCPH1 ZNF177 ZNF559-ZNF177	154 interacting genes: ABCB11 ACY3 AFMID AIDA AKT1 ARPIN BAG4 BANF2 BCL2L14 BID C14orf119 C18orf25 C19orf25 C5orf22 CABP5 CALCOCO2 CALM1 CALM2 CALM3 CATIP CCNK CDA CDKN2D CDPF1 CHMP1A CLIC3 CLK2 CLK3 CPNE7 CRLF3 CRYBB1 DBI DNPH1 DUSP23 DUSP29 EIF4A3 EIF4EBP1 EIF4H EPHB6 EXOSC1 EXOSC5 EXOSC8 FAAP20 FADD FHIT FHL2 FKBP6 FLNA GADD45G GEMIN6 GPKOW GRB2 GUCA1A HDAC7 HMG20A HSPB7 IL36RN IMPDH1 KANK2 KCTD9 KDM8 KRT34 KRTAP5-6 LENG1 LGALS14 LGALSL LMO1 LRATD2 LSM3 LSM5 LSM7 MAP3K7CL MAPRE2 MAPRE3 MEMO1 MIEN1 MKRN3 MLX MORF4L2 MT1M MYG1 MYLIP NAA10 NAV1 NEK6 NGB NHLRC4 NME7 NQO2 NR2C2AP NUDT2 NUDT22 NXT2 PARVG PCBP3 PDE4C PFKFB1 PLSCR4 PM20D2 PMVK PPCDC PPIL1 PPP1R27 PRKAB2 PRPF40A PSMA1 PSMB9 PTS PUF60 RAB32 RFC5 RFPL3 RPIA RPL22 RPRD1B SCOC SEC22A SEPTIN1 SEPTIN3 SEPTIN5 SH3BGRL3 SNRPA SNRPG SREK1IP1 STK16 STK4 SULT2B1 TBC1D22B TCL1A TCP11L1 TEKT4 TEX14 TFPT TNS2 TOLLIP TRIM73 TSEN15 TSSK3 TTC5 TXN TXNL4A TYW3 UBASH3A UBTFL1 VBP1 VCX2 YES1 YOD1 YPEL5 ZBED8 ZNF593 ZNF76 ZNF765 ZSCAN23
Entrez ID		10654	115265
HPRD ID		07404	09663
Ensembl ID		ENSG00000163344	ENSG00000145358
Uniprot IDs		Q15126 Q6FGV9	Q96D03
PDB IDs		3CH4
Enriched GO Terms of Interacting Partners?
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