PAICS and L3MBTL2

Number of citations of the paper that reports this interaction (PubMedID 26871637)
172

Data Source:
BioGRID (two hybrid)

		PAICS	L3MBTL2
Description		phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	L3MBTL histone methyl-lysine binding protein 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Extracellular Exosome	Nucleus Nucleoplasm
	Molecular Function	Phosphoribosylaminoimidazole Carboxylase Activity Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Protein Binding ATP Binding Identical Protein Binding 5-amino-4-imidazole Carboxylate Lyase Activity Cadherin Binding	Chromatin Binding Protein Binding Zinc Ion Binding Methylated Histone Binding Histone Binding
	Biological Process	'de Novo' IMP Biosynthetic Process Purine Nucleobase Biosynthetic Process	Chromatin Organization Negative Regulation Of Transcription, DNA-templated
Pathways		Purine ribonucleoside monophosphate biosynthesis	SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6
Drugs		Aspartic acid
Diseases
GWAS			Adventurousness ( 30643258) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety ( 33859377) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 26192919) Depression ( 29700475) General risk tolerance (MTAG) ( 30643258) Inflammatory bowel disease ( 26192919) Lamb consumption ( 32066663) Major depressive disorder ( 27479909) Neuroticism ( 29255261 27918536) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		21 interacting genes: CDC37 CEP76 CHD3 FXR1 FXR2 L3MBTL2 LNX1 MOB4 NIF3L1 NUDT18 PIAS2 PILRA PRKAG1 PTPRC RAD54L2 RNF4 SMARCD1 TERF1 UBE2I UBE3A ZMYM2	53 interacting genes: AMOTL2 BEND7 BHLHB9 BIVM CARD9 CCDC106 CCDC33 CEP76 CYB5R3 EFHC2 EIF4ENIF1 FAM217B GAS8 GKAP1 GOLGA2 H3C1 H4C1 HSF2BP LNX2 MEAF6 MEOX1 MPP3 NRF1 PAICS PHF10 PIAS1 PICK1 POU6F2 PRKAR1B RBAK REL SSUH2 STAC3 STAM2 TAFA5 TAX1BP1 TBC1D9B TEKT1 THAP1 THAP11 TLE5 TNNI1 TRIM42 TRIM50 TSPYL1 TUBGCP6 XPNPEP3 ZBTB26 ZBTB48 ZFP64 ZFY ZNF467 ZNF829
Entrez ID		10606	83746
HPRD ID		01401	13954
Ensembl ID		ENSG00000128050	ENSG00000100395
Uniprot IDs		P22234	A0A0S2Z5X6 Q969R5
PDB IDs		2H31 6YB8 6YB9	2W0T 3CEY 3F70
Enriched GO Terms of Interacting Partners?
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