TXNRD2 and GTF2H1

Number of citations of the paper that reports this interaction (PubMedID 15625236)
3

Data Source:
BioGRID (two hybrid)

		TXNRD2	GTF2H1
Description		thioredoxin reductase 2	general transcription factor IIH subunit 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Intracellular Membrane-bounded Organelle	Transcription Factor TFIIH Core Complex Nucleoplasm Transcription Factor TFIIH Holo Complex
	Molecular Function	Thioredoxin-disulfide Reductase Activity Protein Binding Flavin Adenine Dinucleotide Binding	Chromatin Binding Protein Binding Thyroid Hormone Receptor Binding
	Biological Process	Response To Oxygen Radical Cell Redox Homeostasis Cellular Oxidant Detoxification	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Repair Nucleotide-excision Repair Transcription By RNA Polymerase I Transcription By RNA Polymerase II Hormone-mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated Phosphorylation Of RNA Polymerase II C-terminal Domain
Pathways		Detoxification of Reactive Oxygen Species	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE
Drugs		Motexafin gadolinium
Diseases
GWAS		Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary angle closure) ( 22922875) Glaucoma (primary open-angle) ( 26752265 33627673 29891935) Intraocular pressure ( 29785010 31959993 30054594) Lean body mass ( 28552196) Staphylococcus aureus infection ( 24847357)	Amyloid A serum levels ( 21124955) Blood protein levels ( 28240269) Pancreatic cancer ( 23180869) Serum metabolite levels ( 33031748 23093944) Survival in pancreatic cancer ( 28470677) Systemic lupus erythematosus ( 33272962)
Interacting Genes		8 interacting genes: BCAS2 GTF2H1 NCOA2 NCOA6 NCOR1 PSMC3 SLC30A9 TADA3	46 interacting genes: ACTN1 AGTRAP AR ATF7IP BRPF1 CCNH CCSER2 CDK7 E2F1 EAF1 ERCC2 ERCC3 ERCC4 ERCC5 ESR1 FHL2 FUBP1 GTF2E1 GTF2E2 GTF2H2 HNF4A HNRNPU HOXC11 JDP2 KIF13A KPNA3 MCM2 MMS19 MNAT1 OGT PIK3R1 PLCG1 POU2AF1 PSMC2 RAD23A REEP5 RXRB TNIP1 TP53 TRIOBP TXNRD2 UBC USHBP1 XPA XPC ZSCAN1
Entrez ID		10587	2965
HPRD ID		18519	01807
Ensembl ID		ENSG00000184470	ENSG00000110768
Uniprot IDs		E7EWK1 Q9NNW7	A0A384MTQ8 P32780
PDB IDs		1W1E	1PFJ 2DII 2RNR 2RUK 2RVB 5GOW 5XV8 6NMI 6O9L 6O9M 7BUL
Enriched GO Terms of Interacting Partners?
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