POMT1 and NUP214

		POMT1	NUP214
Description		protein O-mannosyltransferase 1	nucleoporin 214
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Sarcoplasmic Reticulum	Nuclear Pore Nucleoplasm Cytosol Cytoplasmic Side Of Nuclear Pore
	Molecular Function	Mannosyltransferase Activity Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity Metal Ion Binding	Nuclear Export Signal Receptor Activity Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore
	Biological Process	Carbohydrate Metabolic Process Protein O-linked Glycosylation Multicellular Organism Development Extracellular Matrix Organization Protein O-linked Mannosylation Positive Regulation Of Protein O-linked Glycosylation	Mitotic Cell Cycle RNA Export From Nucleus MRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Cycle
Pathways		Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 O-linked glycosylation	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins HuR (ELAVL1) binds and stabilizes mRNA SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events
Drugs
Diseases
GWAS			Aspartate aminotransferase levels ( 31219225)
Interacting Genes		3 interacting genes: MEOX2 NUP214 POMT2	31 interacting genes: APC ASS1 CHST6 CLEC4G DDX19B DYNC1I1 IPO5 LSS MRPS6 NCBP1 NFX1 NUP107 NUP42 NUP62 NUP88 NUP98 NXF1 NXF2 POMT1 PRRX2 SMAD2 SMAD3 SMAD4 STOM SUMO2 TNPO1 VAV2 XPO1 XPO5 XPOT ZFP36
Entrez ID		10585	8021
HPRD ID		06305	00258
Ensembl ID		ENSG00000130714	ENSG00000126883
Uniprot IDs		A0A140VKE0 Q5JT02 Q9Y6A1	B7ZAV2 P35658
PDB IDs			2OIT 3FHC 3FMO 3FMP 5DIS
Enriched GO Terms of Interacting Partners?
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