SPTLC1 and GTF2IRD1

Number of citations of the paper that reports this interaction (PubMedID 26275350)
10

Data Source:
BioGRID (two hybrid)

		SPTLC1	GTF2IRD1
Description		serine palmitoyltransferase long chain base subunit 1	GTF2I repeat domain containing 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Serine C-palmitoyltransferase Complex SPOTS Complex	Nucleus Nucleoplasm Cytosol
	Molecular Function	Serine C-palmitoyltransferase Activity Protein Binding Pyridoxal Phosphate Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Sphingolipid Metabolic Process Sphingolipid Biosynthetic Process Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Positive Regulation Of Lipophagy Regulation Of Fat Cell Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Transition Between Slow And Fast Fiber
Pathways		Sphingolipid de novo biosynthesis
Drugs		Pyridoxal phosphate Serine
Diseases
GWAS		Bipolar disorder and schizophrenia ( 22688191) Left inferior lateral ventricle volume (Cerebrospinal fluid biomarker status interaction) ( 25140149) Serum immune biomarker levels ( 32066700)	Age at suicide ( 31476763) Aluminium levels ( 26025379) General factor of neuroticism ( 30867560) Neuroticism ( 29255261) Rheumatoid arthritis ( 32723749) Severe influenza A (H1N1) infection ( 26379185) SjÃ¶gren's syndrome ( 24097066) Systemic lupus erythematosus ( 26663301 28714469) Triglyceride levels ( 32203549)
Interacting Genes		5 interacting genes: ABCA1 GABBR2 GTF2IRD1 SPTLC2 TRIM38	25 interacting genes: ALMS1 ATP2C1 CDK20 COL15A1 DCAF6 EXOSC4 GORASP2 HDAC3 HTRA4 KPNA1 KPNA2 KPNA3 KPNA4 MRFAP1L1 PIAS1 PIAS2 PIP4P2 PKP1 PKP2 SELENOS SMAD3 SPTLC1 UBC USP20 ZMYM5
Entrez ID		10558	9569
HPRD ID		05754	08379
Ensembl ID		ENSG00000090054	ENSG00000006704
Uniprot IDs		A0A024R277 O15269 Q6NUL7	E9PFE2 Q9UHL9
PDB IDs		6M4N 6M4O 7CQI 7CQK 7K0I 7K0J 7K0K 7K0L 7K0M 7K0N 7K0O 7K0P 7K0Q	2D99 2DN5 2DZQ 2DZR
Enriched GO Terms of Interacting Partners?
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